Alstergren P, Larsson P T, Kopp S
Department of Clinical Oral Physiology, Institute of Odontology, Karolinska Institutet, Huddinge, Sweden.
Scand J Rheumatol. 2008 Mar-Apr;37(2):155-7. doi: 10.1080/03009740701675635.
This case report presents the clinical and radiographic course of temporomandibular joint (TMJ) involvement in a patient with severe TMJ symptoms from psoriatic arthritis (PsA) resistant to both systemic infliximab and intra-articular glucocorticoid and who therefore received multiple intra-articular infliximab injections for 36 weeks. TMJ symptoms improved after the first bilateral intra-articular infliximab injections but even more so after the second injections. The considerable improvement remained for the 36 weeks studied. Bilateral computerized tomography showed no progression in radiographic changes during the treatment. No adverse reaction was observed from the intra-articular injections.
本病例报告介绍了一名患有银屑病关节炎（PsA）且颞下颌关节（TMJ）受累的患者的临床和影像学病程。该患者患有严重的TMJ症状，对全身用英夫利昔单抗和关节内糖皮质激素均耐药，因此接受了36周的多次关节内英夫利昔单抗注射。首次双侧关节内注射英夫利昔单抗后TMJ症状有所改善，但第二次注射后改善更为明显。在研究的36周内，症状持续显著改善。双侧计算机断层扫描显示治疗期间影像学改变无进展。关节内注射未观察到不良反应。
