Blais Régis, Laurier Claudine, Paré Michèle
Groupe de Recherche Interdisciplinaire en Santé, University of Montreal, Canada.
J Asthma. 2008 Apr;45(3):227-31. doi: 10.1080/02770900701883774.
Suboptimal medication treatment of asthma has been reported. More specifically, short-acting beta 2-agonists are overused, while inhaled corticosteroids are underused. This can be related in part to poor adherence by patients to the prescribed regimen and to professionals' failure to comply with practice guidelines. Feedback seems to have an effect on professional practices related to medication use.
To assess the impact of feedback letters to physicians and pharmacists on their patients' appropriate use of asthma medication.
Two randomized trials were set up in the province of Quebec, Canada: one with physicians and another with pharmacists. A sample of voluntary physicians and pharmacists was randomly assigned to either the experimental group or to the control group. Those in the experimental groups received three consecutive feedback letters over a 9-month period summarizing the asthma medications acquired by their patients over the preceding year. The feedback focused on short-acting beta 2-agonists, long-acting beta 2-agonists and antileukotrienes and provided information on compliance with five appropriate-use criteria. Pharmacists received aggregate profiles and individual profiles with patients' names, while most physicians received aggregate profiles for all their eligible patients. Each mailing also included a pamphlet that summarized practice guidelines on asthma treatment.
Seventy-one physicians and 60 pharmacists participated in the study. Physicians who received the feedback letters did not differ from those in the control group in terms of their proportion of prescriptions compliant with the criteria, either before the feedback or after it (p > 0.05). The before-after difference was also similar between groups. The same was true for pharmacists. However, although the before-after difference for criteria 1 (frequency of use of short-acting beta 2-agonists) and 2 (frequency of use of long-acting beta 2-agonists) did not reach the usual statistical significance threshold of 0.05, the p value was under 0.10.
As designed in this study, feedback provided to physicians did not improve the appropriate use of asthma medication. However, feedback to pharmacists is promising, especially when including patients' names so that pharmacists can intervene more specifically.
已有报道称哮喘药物治疗效果欠佳。更具体地说,短效β2激动剂使用过度,而吸入性糖皮质激素使用不足。这可能部分与患者对规定治疗方案的依从性差以及专业人员未遵守实践指南有关。反馈似乎会对与药物使用相关的专业行为产生影响。
评估给医生和药剂师的反馈信对其患者合理使用哮喘药物的影响。
在加拿大魁北克省开展了两项随机试验:一项针对医生,另一项针对药剂师。将自愿参与的医生和药剂师样本随机分配到实验组或对照组。实验组的人员在9个月内连续收到三封反馈信,总结其患者上一年购买的哮喘药物情况。反馈聚焦于短效β2激动剂、长效β2激动剂和白三烯调节剂,并提供了关于符合五项合理使用标准情况的信息。药剂师收到汇总资料以及包含患者姓名的个人资料,而大多数医生收到的是其所有符合条件患者的汇总资料。每次邮寄还附带一份总结哮喘治疗实践指南的宣传册。
71名医生和60名药剂师参与了该研究。收到反馈信的医生在反馈前后符合标准的处方比例与对照组相比均无差异(p>0.05)。两组的前后差异也相似。药剂师的情况也是如此。然而,尽管标准1(短效β2激动剂的使用频率)和标准2(长效β2激动剂的使用频率)的前后差异未达到通常的0.05统计学显著性阈值,但p值低于0.10。
在本研究设计中,向医生提供的反馈并未改善哮喘药物的合理使用。然而,向药剂师提供反馈很有前景,尤其是包含患者姓名以便药剂师能更有针对性地进行干预时。