Tomcík Jan, Dufek Michal, Hromada Jan, Rektor Ivan, Bares Martin
1st Department of Neurology, St. Anne's University Hospital, Medical Faculty Masaryk University Brno, Czech Republic.
Acta Neurol Belg. 2007 Dec;107(4):112-4.
Miller Fisher syndrome (MFS) is a localized variant of Guillain-Barré syndrome (GBS), characterized by ophthalmoplegia, areflexia, and ataxia. Recent neurophysiological studies have suggested that abnormal terminal axon dysfunction occurs in some cases of Miller Fisher syndrome and Guillain-Barrd syndrome. We present a rare case report of recurrent MFS with abnormal terminal axon dysfunction. To the best of our knowledge, this is the first case report of recurrent MFS with terminal axon dysfunction that persisted up to nine months after the initial presentation of the second attack with positive antiganglioside antibodies and full clinical recovery.
米勒-费希尔综合征(MFS)是吉兰-巴雷综合征(GBS)的一种局部变异型,其特征为眼肌麻痹、腱反射消失和共济失调。最近的神经生理学研究表明,在某些米勒-费希尔综合征和吉兰-巴雷综合征病例中存在异常的终末轴突功能障碍。我们报告一例罕见的复发性MFS伴异常终末轴突功能障碍的病例。据我们所知,这是首例复发性MFS伴终末轴突功能障碍的病例报告,该功能障碍在第二次发作初始表现伴有抗神经节苷脂抗体阳性且临床完全恢复后持续长达9个月。