Sawanyawisuth Kittisak, Tiamkao Somsak, Jitpimolmard Suthipun, Vincent Angela
Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
J Med Assoc Thai. 2007 Feb;90(2):391-3.
Miller-Fisher syndrome (MFS) is a rare variant of Guillain-Barré syndrome (GBS) and is characterized by the clinical triad of ataxia, ophthalmoplegia, and areflexia. The incidence rate in Thailand has not been established but it occurred approximately 1-5% that of GBS. Here, the authors report a Thai patient diagnosed as MFS that had a positive test of antibodies against the ganglioside GQ1b. These antibodies have diagnostic and pathogenic importance to MFS because of high sensitivity and specificity. All other investigations, such as cerebrospinal fluid analysis, electrophysiological studies, and imaging studies had no significant abnormalities. The patient was successfully treated with intravenous immunoglobulin and fully recovered within one month. After eighteen months follow-up, he is still healthy and has had no recurrent symptoms.
米勒-费希尔综合征（MFS）是吉兰-巴雷综合征（GBS）的一种罕见变异型，其特征为共济失调、眼肌麻痹和腱反射消失三联征。泰国的发病率尚未确定，但约占GBS发病率的1%-5%。在此，作者报告一名被诊断为MFS的泰国患者，其抗神经节苷脂GQ1b抗体检测呈阳性。由于这些抗体具有高敏感性和特异性，对MFS具有诊断和致病重要性。所有其他检查，如脑脊液分析、电生理研究和影像学检查均无明显异常。该患者接受静脉注射免疫球蛋白治疗成功，在1个月内完全康复。经过18个月的随访，他仍然健康，没有复发症状。
