天然产物启发的多样性导向合成在药物发现中的应用。
Application of natural product-inspired diversity-oriented synthesis to drug discovery.
作者信息
Marcaurelle Lisa A, Johannes Charles W
机构信息
Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02412, USA.
出版信息
Prog Drug Res. 2008;66:187, 189-216. doi: 10.1007/978-3-7643-8595-8_3.
Natural products have played a critical role in the identification of numerous medicines. Synthetic organic chemistry and combinatorial chemistry strategies such as diversity-oriented synthesis (DOS) have enabled the synthesis of natural product-like compounds. The combination of these approaches has both improved the desired biological properties of natural products as well as the identification of novel compounds. Diversity concepts and strategies to access novel compounds inspired by natural products will be reviewed.
天然产物在众多药物的鉴定中发挥了关键作用。合成有机化学和组合化学策略，如多样性导向合成（DOS），已实现了天然产物类似化合物的合成。这些方法的结合既改善了天然产物所需的生物学特性，又促进了新型化合物的鉴定。本文将综述受天然产物启发获取新型化合物的多样性概念和策略。
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