Farnedi A, Marucci G, Tosi A L, Magrini E, Pession A
Dipartimento di Scienze Oncologiche, Sezione di Anatomia Patologica M. Malpighi, Universith di Bologna, Ospedale Bellaria, Bologna.
Pathologica. 2007 Dec;99(6):424-7.
Choroid plexus tumours are intraventricular papillary lesions that are observed in typical papillomas, atypical papillomas and carcinomas. They usually occur in childhood, and can result in hydrocephalus and increased intracranial pressure. The present paper describes a case of choroid plexus papilloma in an adult woman; cytogenetic analysis of the lesion is also presented, which demonstrated the presence of tumour mosaicism. Compared to the chromosomal aberrations observed in previous cases, those in the present tumour do not show significant differences between papillomas harboured in adults and paediatric patients. Moreover, there was no apparent correlation between genetic alternations in typical and atypical papillomas and prognosis or recurrence.
脉络丛肿瘤是一种发生于脑室内的乳头状病变,可见于典型乳头状瘤、非典型乳头状瘤和脉络丛癌。它们通常发生于儿童期,可导致脑积水和颅内压升高。本文描述了一例成年女性脉络丛乳头状瘤病例;同时还展示了该病变的细胞遗传学分析,结果显示存在肿瘤镶嵌现象。与既往病例中观察到的染色体畸变相比,本肿瘤中的染色体畸变在成人和儿童患者所患的乳头状瘤之间并无显著差异。此外,典型和非典型乳头状瘤中的基因改变与预后或复发之间没有明显关联。