Vajtai I, Varga Z, Aguzzi A
Institute of Neuropathology, University Hospital Zürich, Switzerland.
Histopathology. 1996 Aug;29(2):147-51.
MIB-1 immunohistochemistry was carried out on a retrospective biopsy series of epithelial choroid plexus neoplasms in order to assess the proliferation rate of tumour cells. The material included 14 cases of papilloma (WHO grade I) and five cases of carcinoma (WHO grade III). There was one recurrent tumour in the papilloma group, while three patients with carcinoma experienced recurrence. Choroid plexus obtained at autopsy from paediatric and adult patients with unrelated diseases served as control. The average MIB-1 labelling index of choroid plexus papillomas was 3.7%, while that of carcinomas was 14%, and that of normal choroid plexus was 0.02% to 0.06%. The age and sex of the patients as well as the tumour localization were not found to influence MIB-1 reactivity. The labelling index of recurrent lesions was not significantly different from that of the corresponding primary tumours. High MIB-1 labelling indices were associated with less favourable post-operative outcome in choroid plexus carcinomas and in one papilloma with atypical histology. However, most tumours with atypical histological features did not exhibit distinctive MIB-1 labelling indices. Analysis of growth fraction by MIB-1 immunohistochemistry may prove a useful ancillary method for assessing the malignant potential of choroid plexus neoplasms.
对上皮性脉络丛肿瘤的回顾性活检系列进行了MIB-1免疫组织化学检测，以评估肿瘤细胞的增殖率。材料包括14例乳头状瘤（世界卫生组织I级）和5例癌（世界卫生组织III级）。乳头状瘤组有1例复发性肿瘤，而3例癌患者出现复发。从患有无关疾病的儿科和成年患者尸检中获取的脉络丛作为对照。脉络丛乳头状瘤的平均MIB-1标记指数为3.7%，癌的平均MIB-1标记指数为14%，正常脉络丛的平均MIB-1标记指数为0.02%至0.06%。未发现患者的年龄、性别以及肿瘤定位会影响MIB-1反应性。复发病变的标记指数与相应原发肿瘤的标记指数无显著差异。高MIB-1标记指数与脉络丛癌以及1例具有非典型组织学特征的乳头状瘤术后预后较差相关。然而，大多数具有非典型组织学特征的肿瘤并未表现出独特的MIB-1标记指数。通过MIB-1免疫组织化学分析生长分数可能是评估脉络丛肿瘤恶性潜能的一种有用辅助方法。
