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外科病理学实践中的免疫组织化学:对一种简单、强大但又复杂的工具的当前看法。

Immunohistochemistry in surgical pathology practice: a current perspective of a simple, powerful, yet complex, tool.

作者信息

Jambhekar Nirmala Ajit, Chaturvedi Anshuman C, Madur Bhulaxmi Prakash

机构信息

Department of Pathology, Tata Memorial Hospital, Mumbai, Maharashtra, India.

出版信息

Indian J Pathol Microbiol. 2008 Jan-Mar;51(1):2-11. doi: 10.4103/0377-4929.40382.

DOI:10.4103/0377-4929.40382
PMID:18417841
Abstract

Immunohistochemistry (IHC) is a powerful tool in the surgical pathologists' armamentarium. The requests for IHC and the list of monoclonal antibodies have increased tremendously in the past decade. Issues concerning technical reproducibility, uniformity of interpretation, inter-laboratory comparability, and quality assurance are assuming greater importance due to the increased availability of IHC and its impact on diagnosis and therapy. An attempt has been made to give a current perspective of this simple and yet, in some aspects, a complex tool.

摘要

免疫组织化学(IHC)是外科病理学家武器库中的一项强大工具。在过去十年中,对免疫组织化学的需求以及单克隆抗体的种类大幅增加。由于免疫组织化学的可及性提高及其对诊断和治疗的影响,有关技术可重复性、解读一致性、实验室间可比性和质量保证的问题正变得愈发重要。本文试图对这一简单但在某些方面又很复杂的工具给出当前的观点。

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