在可卡因成瘾的小鼠苍白球中神经连接蛋白3（Nrxn3）上调。
Nrxn3 upregulation in the globus pallidus of mice developing cocaine addiction.
作者信息
Kelai Sabah, Maussion Gilles, Noble Florence, Boni Claudette, Ramoz Nicolas, Moalic Jean-Marie, Peuchmaur Michel, Gorwood Philip, Simonneau Michel
机构信息
INSERM U675, School of Medicine Xavier Bichat, University Denis Diderot, Paris VII, France.
出版信息
Neuroreport. 2008 May 7;19(7):751-5. doi: 10.1097/WNR.0b013e3282fda231.
Dysfunctions affecting the connections of basal ganglia lead to major neurological and psychiatric disorders. We investigated levels of mRNA for three neurexins (Nrxn) and three neuroligins (Nlgn) in the globus pallidus, subthalamic nucleus, and substantia nigra, in control conditions and after short-term exposure to cocaine. The expression of Nrxn2beta and Nlgn3 in the substantia nigra and Nlgn1 in the subthalamic nucleus depended on genetic background. The development of short-term cocaine appetence induced an increase in Nrxn3beta expression in the globus pallidus. Human NRXN3 has recently been linked to several addictions. Thus, NRXN3 adhesion molecules may play an important role in the synaptic plasticity of neurons involved in the indirect pathways of basal ganglia, in which they regulate reward-related learning.
影响基底神经节连接的功能障碍会导致严重的神经和精神疾病。我们研究了在对照条件下以及短期接触可卡因后，苍白球、丘脑底核和黑质中三种神经连接蛋白（Nrxn）和三种神经配蛋白（Nlgn）的mRNA水平。黑质中Nrxn2β和Nlgn3的表达以及丘脑底核中Nlgn1的表达取决于遗传背景。短期可卡因嗜好的形成导致苍白球中Nrxn3β表达增加。人类NRXN3最近已与多种成瘾行为相关联。因此，NRXN3黏附分子可能在基底神经节间接通路中参与的神经元突触可塑性中发挥重要作用，在该通路中它们调节与奖赏相关的学习。
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