Guzman Maria G, Kouri Gustavo
Virology Department, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, Institute of Tropical Medicine, Pedro Kouri, Habana, Cuba.
Trans R Soc Trop Med Hyg. 2008 Jun;102(6):522-3. doi: 10.1016/j.trstmh.2008.03.001. Epub 2008 Apr 16.
In 1987, Kouri et al. published in Transactions their integral hypothesis to explain the development of dengue haemorrhagic fever (DHF) epidemics (Kouri, G.P., Guzmán, M.G., Bravo, J.R., 1987. Why dengue haemorrhagic fever in Cuba? 2. An integral analysis. Trans. R. Soc. Trop. Med. Hyg. 81, 821-823). Based on observations carried out during the 1981 Cuban DHF epidemic, the authors integrated in one model the most advanced knowledge at that time. Observations in the last 20 years confirm the importance of this multifactorial and unifying view of the problem, where the interaction between the host, the virus and the vector in an epidemiological and ecosystem setting might determine DHF as a final outcome. Investigations on the interaction among host, virus and mosquito with an ecosystemic view are needed.
1987年，库里等人在《汇刊》上发表了他们的整体假说，以解释登革出血热（DHF）疫情的发展情况（库里，G.P.，古兹曼，M.G.，布拉沃，J.R.，1987年。古巴为何会出现登革出血热？2. 整体分析。《皇家热带医学与卫生学会汇刊》81卷，第821 - 823页）。基于1981年古巴登革出血热疫情期间所做的观察，作者们将当时最先进的知识整合到了一个模型中。过去20年的观察证实了这种对该问题的多因素且统一观点的重要性，即在流行病学和生态系统背景下，宿主、病毒和媒介之间的相互作用可能决定最终是否会出现登革出血热。需要从生态系统角度对宿主、病毒和蚊子之间的相互作用展开研究。
