氟哌啶醇与昂丹司琼预防术后恶心和呕吐的比较。
Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting.
作者信息
Rosow Carl E, Haspel Kenneth L, Smith Sarah E, Grecu Loreta, Bittner Edward A
机构信息
Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114, USA.
出版信息
Anesth Analg. 2008 May;106(5):1407-9, table of contents. doi: 10.1213/ane.0b013e3181609022.
BACKGROUND
Haloperidol is effective for postoperative nausea and vomiting prophylaxis, but there are almost no data comparing it to 5-HT(3) antagonists.
METHODS
Two hundred forty-four adults were randomized to receive i.v. haloperidol 1 mg or ondansetron 4 mg, during general anesthesia. Nausea, vomiting, need for rescue, sedation, extrapyramidal effects, QTc intervals, and time to postanesthesia care unit discharge were evaluated with a third-party blind design.
RESULTS
There was no intergroup difference in any measure of efficacy or toxicity. Haloperidol and ondansetron subjects (78.2% and 76.8%) had complete response. Postoperatively, prolonged QTc occurred in 28.9% and 22.1% (N.S.).
CONCLUSIONS
In a mixed surgical population, the efficacy and toxicity of postoperative nausea and vomiting prophylaxis with haloperidol 1 mg was not significantly different from ondansetron 4 mg.
背景
氟哌啶醇对预防术后恶心和呕吐有效，但几乎没有数据将其与5-羟色胺（3）拮抗剂进行比较。
方法
244名成年人在全身麻醉期间被随机分为静脉注射1毫克氟哌啶醇组或4毫克昂丹司琼组。采用第三方盲法设计评估恶心、呕吐、急救需求、镇静、锥体外系反应、QTc间期以及进入麻醉后护理病房的时间。
结果
在任何疗效或毒性指标上，两组之间均无差异。氟哌啶醇组和昂丹司琼组（分别为78.2%和76.8%）有完全缓解。术后，QTc延长分别发生在28.9%和22.1%的患者中（无统计学差异）。
结论
在混合手术人群中，1毫克氟哌啶醇预防术后恶心和呕吐的疗效及毒性与4毫克昂丹司琼无显著差异。
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