Kobayashi Kazuma, Nakajima Kazunori
Department of Anatomy, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.
Brain Nerve. 2008 Apr;60(4):395-403.
The development of cerebral cortex is regulated by complex mechanisms. Various classes of neurons migrate from the proliferative zones to the cortex according to a spatiotemporal manner. There are two distinct modes of neuronal migration: radial migration and tangential migration. In the benefit of the advancement of research techniques such as in utero electroporation and time-lapse observation of living tissues, more aspects of the cell and molecular mechanisms that control these two migration modes and their roles in the cortical development have been clarified.
大脑皮层的发育受复杂机制调控。各类神经元按照时空方式从增殖区迁移至皮层。神经元迁移存在两种不同模式：径向迁移和切向迁移。得益于子宫内电穿孔和活组织延时观察等研究技术的进步，控制这两种迁移模式的细胞和分子机制的更多方面及其在皮层发育中的作用已得以阐明。
