Borioni Raoul, De Paulis Ruggero, Tomai Fabrizio, Welter Luca, Fratticci Laura, Caprara Elisabetta, Albano Paolo, Garofalo Mariano
U.O. di Chirurgia Vascolare, European Hospital Via Portuense, 700 00149 Roma E-mail: raoulborioni@alice. it U.O. di Chirurgia Vascolare, Aurelia Hospital, Roma.
G Ital Cardiol (Rome). 2008 Mar;9(3):194-8.
The presence of significant carotid artery disease in patients undergoing coronary artery bypass grafting has been reported to be as high as 17%. The optimal management of patients with significant coronary and carotid artery disease remains controversial. In this study, we analyze our recent experience with patients who underwent synchronous carotid endarterectomy (CEA) and coronary artery bypass grafting.
We reviewed the early outcome of 68 patients (56 males, 12 females, mean age 71.1 years, range 53-88 years) who underwent simultaneous CEA and coronary artery revascularization between January 2005 and June 2007. The frequency of unstable or ulcerated plaques was determined in symptomatic and asymptomatic patients.
Death for myocardial infarction occurred in 3 patients (4.4%). Stroke was found in 1 patient (1.4%). Combined 30-day stroke/mortality rate was 5.8%. The frequency of unstable or ulcerated plaques was 60.3% (41/68). An unstable stenosis was present in 23 out of 42 asymptomatic patients (54.7%).
Patients suffering from a concomitant coronary and carotid artery occlusive disease represent a high-risk population whose management is still controversial. A modern approach to combined CEA and coronary artery bypass grafting may be safe. The high frequency of unstable carotid lesions in asymptomatic patients suggests to treat every stenosis > 75% in candidates to coronary artery bypass grafting. Carotid artery stenting should be avoided in the majority of cases, considering the possibility of unstable carotid stenosis and the atherosclerotic involvement of aortic arch.
据报道,接受冠状动脉搭桥手术的患者中,严重颈动脉疾病的发生率高达17%。对于患有严重冠状动脉和颈动脉疾病的患者,最佳治疗方案仍存在争议。在本研究中,我们分析了近期同期行颈动脉内膜切除术(CEA)和冠状动脉搭桥手术患者的经验。
我们回顾了2005年1月至2007年6月期间68例(56例男性,12例女性,平均年龄71.1岁,范围53 - 88岁)同期行CEA和冠状动脉血运重建术患者的早期结局。确定有症状和无症状患者中不稳定或溃疡斑块的发生率。
3例患者(4.4%)死于心肌梗死。1例患者(1.4%)发生卒中。30天卒中/死亡率为5.8%。不稳定或溃疡斑块的发生率为60.3%(41/68)。42例无症状患者中有23例(54.7%)存在不稳定狭窄。
患有冠状动脉和颈动脉闭塞性疾病的患者是高危人群,其治疗仍存在争议。现代的CEA和冠状动脉搭桥联合手术方法可能是安全的。无症状患者中颈动脉不稳定病变的高发生率提示,对于冠状动脉搭桥手术候选者,应治疗每一处狭窄>75%的病变。考虑到颈动脉狭窄不稳定和主动脉弓动脉粥样硬化累及的可能性,大多数情况下应避免颈动脉支架置入术。