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同期颈动脉内膜切除术和冠状动脉搭桥手术:体外循环和非体外循环技术的结果

Concomitant carotid endarterectomy and coronary bypass surgery: outcome of on-pump and off-pump techniques.

作者信息

Mishra Yugal, Wasir Harpreet, Kohli Vijay, Meharwal Zile Singh, Malhotra Rajneesh, Mehta Yatin, Trehan Naresh

机构信息

Department of Cardiovascular Surgery, Escorts Heart Institute and Research Centre, New Delhi, India.

出版信息

Ann Thorac Surg. 2004 Dec;78(6):2037-42; discussion 2042-3. doi: 10.1016/j.athoracsur.2004.06.003.

Abstract

BACKGROUND

There continues to be a dilemma regarding the best means of surgical management of significant carotid artery disease in patients requiring coronary artery bypass surgery. A combined approach of coronary artery bypass and carotid endarterectomy has shown good results in patients with concomitant carotid and coronary artery disease. We reviewed our results of coronary artery surgery using conventional cardiopulmonary bypass or off-pump techniques and carotid endarterectomy done as a combined procedure.

METHODS

Between January 1996 and June 2002, 358 patients underwent concomitant coronary artery bypass and carotid endarterectomy. There were 140 males (84.3%) and 26 females (15.7%) in group I. Group II consisted of 158 males (82.3%) and 34 females (17.7%). One hundred sixty-six patients (group I) were done off pump whereas in 192 patients (group II), the procedure was done using conventional cardiopulmonary bypass. Carotid endarterectomy was performed before coronary artery bypass surgery in both groups.

RESULTS

The average number of grafts were 3.4 +/- 0.8 with average operative time of 4.2 +/- 0.4 hours in group I, and 3.3 +/- 0.8 graft with operative time of 5.3 +/- 1.2 hours in group II (p = 0.239 and p < 0.001, respectively). There were 2 deaths (1.2%) in group I and 3 deaths (1.6%) in group II (p = 0.870). No patient from group I and 1 patient (0.5%) from group II had postoperative stroke (p = 0.941). Mean hospital stay was 9.0 +/- 1.2 days in group I and 11.2 +/- 1.7 days in group II (p < 0.001). At mean follow-up of 2.8 +/- 0.9 years in group I, 2 patients (1.2%) had late death due to cardiac failure and contralateral carotid endarterectomy was done in 2 patients (1.2%). Group II had mean follow-up of 2.4 +/- 0.6 years, during which 4 patients (2.1%) had late death and contralateral carotid endarterectomy was done in 3 patients (1.6%). Late stroke was seen in 1 patient (0.6%) from group I and 2 patients (1.0%) from group II.

CONCLUSIONS

Concomitant carotid endarterectomy and coronary artery bypass is a safe and effective procedure in patients with significant coronary and carotid artery disease. Equally good results can be reproduced using cardiopulmonary bypass or off-pump techniques for coronary artery surgery, with low morbidity, mortality, and good long-term results.

摘要

背景

对于需要冠状动脉搭桥手术的严重颈动脉疾病患者,手术管理的最佳方式仍然存在困境。冠状动脉搭桥术和颈动脉内膜切除术的联合方法已在伴有颈动脉和冠状动脉疾病的患者中显示出良好效果。我们回顾了采用传统体外循环或非体外循环技术进行冠状动脉手术以及作为联合手术进行颈动脉内膜切除术的结果。

方法

1996年1月至2002年6月期间,358例患者接受了冠状动脉搭桥术和颈动脉内膜切除术。第一组有140名男性(84.3%)和26名女性(15.7%)。第二组由158名男性(82.3%)和34名女性(17.7%)组成。166例患者(第一组)采用非体外循环手术,而192例患者(第二组)采用传统体外循环进行手术。两组均在冠状动脉搭桥手术前进行颈动脉内膜切除术。

结果

第一组平均移植血管数为3.4±0.8根,平均手术时间为4.2±0.4小时;第二组平均移植血管数为3.3±0.8根,手术时间为5.3±1.2小时(分别为p = 0.239和p < 0.001)。第一组有2例死亡(1.2%),第二组有3例死亡(1.6%)(p = 0.870)。第一组无患者发生术后中风,第二组有1例患者(0.5%)发生术后中风(p = 0.941)。第一组平均住院时间为9.0±1.2天,第二组为11.2±1.7天(p < 0.001)。第一组平均随访2.8±0.9年,2例患者(1.2%)因心力衰竭晚期死亡,2例患者(1.2%)进行了对侧颈动脉内膜切除术。第二组平均随访2.4±0.6年,在此期间4例患者(2.1%)晚期死亡,3例患者(1.6%)进行了对侧颈动脉内膜切除术。第一组有1例患者(0.6%)发生晚期中风,第二组有2例患者(1.0%)发生晚期中风。

结论

对于患有严重冠状动脉和颈动脉疾病的患者,同期进行颈动脉内膜切除术和冠状动脉搭桥术是一种安全有效的手术。采用体外循环或非体外循环技术进行冠状动脉手术均可取得同样良好的效果,发病率、死亡率低,长期效果良好。

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