Alexiades-Armenakas Macrene R, Dover Jeffrey S, Arndt Kenneth A
Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA.
J Am Acad Dermatol. 2008 May;58(5):719-37; quiz 738-40. doi: 10.1016/j.jaad.2008.01.003.
The drive to attain cosmetic facial enhancement with minimal risk and rapid recovery has inspired the field of nonsurgical skin rejuvenation. Laser resurfacing was introduced in the 1980s with continuous wave carbon dioxide (CO(2)) lasers; however, because of a high rate of side effects, including scarring, short-pulse, high-peak power, and rapidly scanned, focused-beam CO(2) lasers and normal-mode erbium-doped yttrium aluminium garnet lasers were developed, which remove skin in a precisely controlled manner. The prolonged 2-week recovery time and small but significant complication risk prompted the development of non-ablative and, more recently, fractional resurfacing in order to minimize risk and shorten recovery times. Nonablative resurfacing produces dermal thermal injury to improve rhytides and photodamage while preserving the epidermis. Fractional resurfacing thermally ablates microscopic columns of epidermal and dermal tissue in regularly spaced arrays over a fraction of the skin surface. This intermediate approach increases efficacy as compared to nonablative resurfacing, but with faster recovery as compared to ablative resurfacing. Neither nonablative nor fractional resurfacing produces results comparable to ablative laser skin resurfacing, but both have become much more popular than the latter because the risks of treatment are limited in the face of acceptable improvement.
At the completion of this learning activity, participants should be familiar with the spectrum of lasers and light technologies available for skin resurfacing, published studies of safety and efficacy, indications, methodologies, side effects, complications, and management.
通过最小化风险和快速恢复来实现面部美容提升的需求推动了非手术皮肤年轻化领域的发展。20世纪80年代,连续波二氧化碳(CO₂)激光被引入用于激光换肤;然而,由于包括瘢痕形成在内的副作用发生率较高,短脉冲、高峰值功率且快速扫描的聚焦束CO₂激光以及常规模式掺铒钇铝石榴石激光得以开发,它们能够以精确可控的方式去除皮肤。长达2周的恢复时间以及虽小但显著的并发症风险促使了非剥脱性以及最近的分次换肤技术的发展,以将风险降至最低并缩短恢复时间。非剥脱性换肤产生真皮热损伤以改善皱纹和光损伤,同时保留表皮。分次换肤在皮肤表面的一部分区域以规则间隔的阵列方式对微小的表皮和真皮组织柱进行热消融。与非剥脱性换肤相比,这种中间方法提高了疗效,但与剥脱性换肤相比恢复更快。非剥脱性换肤和分次换肤都无法产生与剥脱性激光皮肤换肤相当的效果,但由于在可接受的改善情况下治疗风险有限,两者都比后者更受欢迎。
在完成本学习活动后,参与者应熟悉可用于皮肤换肤的激光和光技术范围、已发表的安全性和有效性研究、适应症、方法、副作用、并发症及处理方法。