Ramot Yuval, Steiner Michal, Vazana Udi, Nahear Rotem, Suliman Neria, Friedman David J, Noach Salman, Nyska Abraham
Department of Dermatology, Hadassah Medical Center, Jerusalem, Israel.
The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Lasers Surg Med. 2025 Jul;57(5):405-414. doi: 10.1002/lsm.70022. Epub 2025 May 4.
This exploratory study was aimed to evaluate the safety and preliminary efficacy of Epicare, a 1940 nm thulium-doped yttrium aluminum perovskite (Tm:YAP) laser, for fractional skin ablation in a swine model. The goal was to assess collagen remodeling and tissue responses across varied laser settings to optimize skin resurfacing applications.
Two female domestic swine were subjected to controlled fractional laser ablation using Epicare across 52 marked abdominal sites with varying energy settings. Macroscopic examinations of ablated sites were conducted immediately following ablation and at 1, 3, 7, 14, 22, and 29 days postablation. Histopathological evaluation was conducted immediately posttreatment, and at 1, 7, and 29 days postablation. Observed parameters included epidermal regeneration, dermal remodeling, inflammation, and collagen deposition.
Macroscopic evaluations revealed a fractional, clear, and immediate impact of ablation, consisting primarily of erythema and edema, which resolved without complications by Day 14. Histopathological analysis indicated focal, cylinder-like structures associated with necrotic epidermis and dermis, which healed progressively (i.e. from day 1), transitioning to complete epidermal regeneration by Day 7 for most energy settings. By Day 29, advanced collagen deposition and no residual inflammation indicated effective dermal remodeling, consistent with rapid healing and minimal adverse reactions.
Epicare demonstrated a favorable safety profile and effective tissue ablation. These findings support the laser's potential for dermatologic applications while emphasizing the need for further investigation to confirm its efficacy and optimal settings in human clinical trials.
本探索性研究旨在评估1940纳米掺铥钇铝石榴石（Tm:YAP）激光Epicare在猪模型中进行皮肤磨削术的安全性和初步疗效。目标是评估不同激光参数设置下的胶原重塑和组织反应，以优化皮肤表面重塑应用。
对两只雌性家猪的52个标记腹部部位使用Epicare进行可控的分次激光消融，设置不同的能量参数。在消融后立即以及消融后1、3、7、14、22和29天对消融部位进行宏观检查。在治疗后立即以及消融后1、7和29天进行组织病理学评估。观察参数包括表皮再生、真皮重塑、炎症和胶原沉积。
宏观评估显示消融具有分次、明显且即时的影响，主要表现为红斑和水肿，在第14天时这些症状无并发症地消退。组织病理学分析表明存在与坏死表皮和真皮相关的局灶性圆柱状结构，其逐渐愈合（即从第1天开始），对于大多数能量设置，到第7天时过渡为完全的表皮再生。到第29天时，大量的胶原沉积且无残留炎症表明真皮重塑有效，这与快速愈合和最小的不良反应一致。
Epicare显示出良好的安全性和有效的组织消融效果。这些发现支持了该激光在皮肤科应用中的潜力，同时强调需要进一步研究以在人体临床试验中确认其疗效和最佳参数设置。
