使用促性腺激素释放激素（GnRH）拮抗剂进行预处理以预防长效GnRH激动剂的激发效应：一项初步研究的结果。
Pretreatment with gonadotropin-releasing hormone (GnRH) antagonists to prevent the flare-up effect of long-acting GnRH agonists: results of a pilot study.
作者信息
Mueller Andreas, Maltaris Theodoros, Häberle Lothar, Hoffmann Inge, Beckmann Matthias W, Dittrich Ralf
机构信息
Department of Obstetrics and Gynecology, Erlangen University Hospital, Erlangen, Germany.
出版信息
Fertil Steril. 2009 Feb;91(2):647-8. doi: 10.1016/j.fertnstert.2007.11.066. Epub 2008 Apr 18.
Abstract
This study evaluated in vivo whether the flare-up effect of GnRH agonists can be suppressed through pretreatment with a GnRH antagonist. The classic flare-up effect caused by 3.8 mg goserelin acetate could not be suppressed through pretreatment using a single dosage of 3.24 mg cetrorelix acetate.
摘要
本研究在体内评估了促性腺激素释放激素（GnRH）拮抗剂预处理是否能够抑制GnRH激动剂的激发效应。醋酸戈舍瑞林3.8mg所引发的典型激发效应，无法通过单次给予3.24mg醋酸西曲瑞克预处理得到抑制。
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