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促性腺激素释放激素（GnRH）激动剂与 GnRH 拮抗剂联合应用于化疗前可减少但不能完全预防促卵泡激素激增。

Combination of gonadotropin-releasing hormone (GnRH) agonists with GnRH antagonists before chemotherapy reduce but does not completely prevent a follicle-stimulating hormone flare-up.

机构信息

University Women's Hospital, Department of Gynaecological Endocrinology and Reproductive Medicine, Berne, Switzerland.

出版信息

Fertil Steril. 2011 Jan;95(1):452-4. doi: 10.1016/j.fertnstert.2010.08.053. Epub 2010 Sep 25.

DOI:10.1016/j.fertnstert.2010.08.053
PMID:20869706
Abstract

Increasing evidence supports GnRH agonists to be an effective treatment to preserve ovarian function during chemotherapy, but the initial flare-up of FSH during the first week after GnRH agonist application still limits its use. The combination of GnRH agonists with GnRH antagonists might solve this problem to some extent as the addition of GnRH antagonists at least significantly reduces the FSH flare-up.

摘要

越来越多的证据支持 GnRH 激动剂是一种有效的治疗方法，可以在化疗期间保护卵巢功能，但 GnRH 激动剂应用后第一周 FSH 的初始激增仍然限制了其使用。 GnRH 激动剂与 GnRH 拮抗剂的联合应用在一定程度上可能解决这个问题，因为 GnRH 拮抗剂的添加至少显著减少了 FSH 的激增。

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