DeBosch Brian J, Muslin Anthony J
Center for Cardiovascular Research, John Milliken Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
J Mol Cell Cardiol. 2008 May;44(5):855-64. doi: 10.1016/j.yjmcc.2008.03.008. Epub 2008 Mar 19.
The development, growth, function and metabolism of the heart are regulated by extracellular growth factors, cytokines and ligands. In this review, the role of insulin and insulin-like growth factors in the regulation of cardiac growth will be discussed. In addition, the role of insulin- and insulin-like growth factor-stimulated intracellular signaling proteins in cardiac growth will be reviewed.
心脏的发育、生长、功能及代谢受细胞外生长因子、细胞因子和配体的调节。在本综述中,将讨论胰岛素和胰岛素样生长因子在心脏生长调节中的作用。此外,还将综述胰岛素和胰岛素样生长因子刺激的细胞内信号蛋白在心脏生长中的作用。