• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Insulin signaling pathways and cardiac growth.胰岛素信号通路与心脏生长
J Mol Cell Cardiol. 2008 May;44(5):855-64. doi: 10.1016/j.yjmcc.2008.03.008. Epub 2008 Mar 19.
2
The role of tyrosine phosphorylation in the regulation of insulin and insulin-like growth factor-I receptor kinase activities.酪氨酸磷酸化在胰岛素及胰岛素样生长因子-I受体激酶活性调节中的作用。
Adv Exp Med Biol. 1986;205:165-83. doi: 10.1007/978-1-4684-5209-9_8.
3
The Roles of the IGF Axis in the Regulation of the Metabolism: Interaction and Difference between Insulin Receptor Signaling and IGF-I Receptor Signaling.IGF 轴在代谢调节中的作用：胰岛素受体信号和 IGF-1 受体信号之间的相互作用和差异。
Int J Mol Sci. 2021 Jun 24;22(13):6817. doi: 10.3390/ijms22136817.
4
The proliferating role of insulin and insulin-like growth factors in cancer.胰岛素和胰岛素样生长因子在癌症中的增殖作用。
Trends Endocrinol Metab. 2010 Oct;21(10):610-8. doi: 10.1016/j.tem.2010.06.007. Epub 2010 Jul 19.
5
Insulin/Insulin-like growth factor signaling controls non-Dauer developmental speed in the nematode Caenorhabditis elegans.胰岛素/胰岛素样生长因子信号控制线虫秀丽隐杆线虫非 dauer 发育速度。
Genetics. 2011 Jan;187(1):337-43. doi: 10.1534/genetics.110.123323. Epub 2010 Oct 13.
6
Insulin receptor substrate signaling controls cardiac energy metabolism and heart failure.胰岛素受体底物信号传导控制心脏能量代谢和心力衰竭。
J Endocrinol. 2017 Jun;233(3):R131-R143. doi: 10.1530/JOE-16-0679. Epub 2017 Apr 5.
7
Insulin and insulin-like growth factors in the CNS.中枢神经系统中的胰岛素及胰岛素样生长因子
Trends Neurosci. 1988 Mar;11(3):107-11. doi: 10.1016/0166-2236(88)90155-5.
8
Disrupting insulin-like growth factor signaling as a potential cancer therapy.破坏胰岛素样生长因子信号传导作为一种潜在的癌症治疗方法。
Mol Cancer Ther. 2007 Jan;6(1):1-12. doi: 10.1158/1535-7163.MCT-06-0080.
9
The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration.胰岛素样生长因子信号通路在心脏发育和再生中的作用。
Int J Mol Sci. 2021 Dec 26;23(1):234. doi: 10.3390/ijms23010234.
10
Insulin-like growth factors and insulin: at the crossroad between tumor development and longevity.胰岛素样生长因子与胰岛素：肿瘤发生与长寿的十字路口。
J Gerontol A Biol Sci Med Sci. 2012 Jun;67(6):640-51. doi: 10.1093/gerona/gls065. Epub 2012 Mar 15.

引用本文的文献

1
Selected Pathway Analyses to Gain Mechanistic Insights into the Pathogenesis of Feline Hypertrophic Cardiomyopathy.选择通路分析以深入了解猫肥厚性心肌病发病机制的机理
Int J Mol Sci. 2025 Jul 5;26(13):6497. doi: 10.3390/ijms26136497.
2
Vascular and Myocardial Structure and Function in Adolescents with Type 1 Diabetes: The CARDEA Study.1型糖尿病青少年的血管和心肌结构与功能：CARDEA研究
Pediatr Diabetes. 2023 Aug 24;2023:8662038. doi: 10.1155/2023/8662038. eCollection 2023.
3
"An unprecedented occurrence: a case report of pulmonary hypertension manifestation in Donohue syndrome".“史无前例的情况：Donohue 综合征表现为肺动脉高压的病例报告”。
BMC Pediatr. 2024 May 11;24(1):327. doi: 10.1186/s12887-024-04714-1.
4
Insulin signaling in the heart is impaired by growth hormone: a direct and early event.生长激素损害心脏中的胰岛素信号转导：一种直接且早期的事件。
J Mol Endocrinol. 2022 Jun 23;69(2):357-376. doi: 10.1530/JME-21-0242. Print 2022 Aug 1.
5
Hypertrophic Cardiomyopathy in Infants from the Perspective of Cardiomyocyte Maturation.从心肌细胞成熟角度看婴儿肥厚型心肌病
Korean Circ J. 2021 Sep;51(9):733-751. doi: 10.4070/kcj.2021.0153. Epub 2021 Jun 18.
6
Leptin Attenuates Cardiac Hypertrophy in Patients With Generalized Lipodystrophy.瘦素可减轻全身性脂肪营养不良患者的心脏肥大。
J Clin Endocrinol Metab. 2021 Oct 21;106(11):e4327-e4339. doi: 10.1210/clinem/dgab499.
7
Intrauterine Growth Restriction and Hypertrophic Cardiomyopathy as Prenatal Ultrasound Findings in a Case of Leprechaunism.宫内生长受限和肥厚型心肌病作为妖精貌综合征病例的产前超声检查结果
Mol Syndromol. 2020 Nov;11(4):223-227. doi: 10.1159/000509837. Epub 2020 Sep 2.
8
Short high-fat diet interferes with the physiological maturation of the late adolescent mouse heart.短期高脂肪饮食会干扰青春期后期小鼠心脏的生理成熟。
Physiol Rep. 2020 Jul;8(13):e14474. doi: 10.14814/phy2.14474.
9
Myocardium Metabolism in Physiological and Pathophysiological States: Implications of Epicardial Adipose Tissue and Potential Therapeutic Targets.心肌在生理和病理状态下的代谢：心外膜脂肪组织的意义和潜在的治疗靶点。
Int J Mol Sci. 2020 Apr 10;21(7):2641. doi: 10.3390/ijms21072641.
10
Oxidative Stress in Radiation-Induced Cardiotoxicity.辐射诱导性心脏毒性中的氧化应激。
Oxid Med Cell Longev. 2020 Mar 1;2020:3579143. doi: 10.1155/2020/3579143. eCollection 2020.

本文引用的文献

1
IGF-I treatment of insulin resistance.胰岛素样生长因子-I治疗胰岛素抵抗。
Eur J Endocrinol. 2007 Aug;157 Suppl 1:S51-6. doi: 10.1530/EJE-07-0271.
2
Effects of growth hormone on exercise capacity and cardiopulmonary performance in patients with chronic heart failure.生长激素对慢性心力衰竭患者运动能力和心肺功能的影响。
J Clin Endocrinol Metab. 2007 Nov;92(11):4218-23. doi: 10.1210/jc.2007-1189. Epub 2007 Aug 14.
3
Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes.蛋白激酶C-λ在肌肉中的特异性敲除会损害葡萄糖转运，并诱发代谢综合征和糖尿病综合征。
J Clin Invest. 2007 Aug;117(8):2289-301. doi: 10.1172/JCI31408.
4
Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice.Cbl-b基因缺陷增强了小鼠脂肪组织中巨噬细胞的浸润和活化，并导致外周胰岛素抵抗。
Diabetes. 2007 Oct;56(10):2511-22. doi: 10.2337/db06-1768. Epub 2007 Jun 29.
5
Diabetic cardiomyopathy revisited.再探糖尿病性心肌病
Circulation. 2007 Jun 26;115(25):3213-23. doi: 10.1161/CIRCULATIONAHA.106.679597.
6
Pharmacologic therapy in growth hormone disorders and the heart.生长激素紊乱与心脏的药物治疗
Curr Med Chem. 2007;14(13):1399-407. doi: 10.2174/092986707780831195.
7
Cardiovascular actions of insulin.胰岛素的心血管作用。
Endocr Rev. 2007 Aug;28(5):463-91. doi: 10.1210/er.2007-0006. Epub 2007 May 24.
8
PI3K(p110alpha) inhibitors as anti-cancer agents: minding the heart.作为抗癌药物的PI3K（p110α）抑制剂：关注心脏
Cell Cycle. 2007 Apr 15;6(8):910-3. doi: 10.4161/cc.6.8.4124. Epub 2007 Apr 7.
9
Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance.骨髓特异性Cap基因缺失可预防高脂饮食诱导的胰岛素抵抗。
Nat Med. 2007 Apr;13(4):455-62. doi: 10.1038/nm1550. Epub 2007 Mar 11.
10
Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function.胰岛素和胰岛素样生长因子1受体信号传导在心脏发育和功能中的重要作用。
Mol Cell Biol. 2007 Mar;27(5):1649-64. doi: 10.1128/MCB.01110-06. Epub 2006 Dec 22.

胰岛素信号通路与心脏生长

Insulin signaling pathways and cardiac growth.

作者信息

DeBosch Brian J, Muslin Anthony J

机构信息

Center for Cardiovascular Research, John Milliken Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

出版信息

J Mol Cell Cardiol. 2008 May;44(5):855-64. doi: 10.1016/j.yjmcc.2008.03.008. Epub 2008 Mar 19.

DOI:10.1016/j.yjmcc.2008.03.008
PMID:18423486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2442827/
Abstract

The development, growth, function and metabolism of the heart are regulated by extracellular growth factors, cytokines and ligands. In this review, the role of insulin and insulin-like growth factors in the regulation of cardiac growth will be discussed. In addition, the role of insulin- and insulin-like growth factor-stimulated intracellular signaling proteins in cardiac growth will be reviewed.

摘要

心脏的发育、生长、功能及代谢受细胞外生长因子、细胞因子和配体的调节。在本综述中，将讨论胰岛素和胰岛素样生长因子在心脏生长调节中的作用。此外，还将综述胰岛素和胰岛素样生长因子刺激的细胞内信号蛋白在心脏生长中的作用。