重症监护中的遗传学：一个工具箱。

Genetics in critical care: a toolbox.

作者信息

Beery Theresa A

机构信息

College of Nursing, University of Cincinnati, Cincinnati, OH 45221-0038, USA.

出版信息

Crit Care Nurs Clin North Am. 2008 Jun;20(2):139-48,v. doi: 10.1016/j.ccell.2008.01.002.

DOI:10.1016/j.ccell.2008.01.002

PMID:18424344

Abstract

Becoming comfortable with the onslaught of genetic information requires a familiarity with genetics terminology and basic molecular genetics. Caring for the genetic health of our patients requires an additional appreciation of genetic testing and screening issues and new areas of study with strange-sounding names, such as proteomics, nutrigenomics, and epigenetics. This article provides an overview of basic genetic principles and terminology with applications to critical care patients. It lays a foundation to support understanding of the other articles in this issue. An appreciation of genetics (the study of heredity) and genomics (the study of the interaction of genes within an organism) has an important place in the knowledge base of every critical care clinician.

摘要

要适应基因信息的冲击，需要熟悉遗传学术语和基本分子遗传学。关注患者的基因健康，还需要进一步了解基因检测和筛查问题以及一些名称奇特的新研究领域，如蛋白质组学、营养基因组学和表观遗传学。本文概述了基本的遗传学原理和术语，并将其应用于重症监护患者。它为理解本期的其他文章奠定了基础。了解遗传学（对遗传的研究）和基因组学（对生物体内基因相互作用的研究）在每位重症监护临床医生的知识库中都占有重要地位。