通过钯催化氢化对环状氨基磺酸酯进行对映选择性合成。
Enantioselective synthesis of cyclic sulfamidates via Pd-catalyzed hydrogenation.
作者信息
Wang You-Qing, Yu Chang-Bin, Wang Da-Wei, Wang Xiao-Bing, Zhou Yong-Gui
机构信息
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China.
出版信息
Org Lett. 2008 May 15;10(10):2071-4. doi: 10.1021/ol800591u. Epub 2008 Apr 22.
PMID:18426218
Abstract
Using Pd(CF3CO2) 2/(S,S)-f-binaphane as the catalyst, an efficient enantioselective synthesis of cyclic sulfamidates was developed via asymmetric hydrogenation of the corresponding cyclic imines in 2,2,2-trifluoroethanol at room temperature with high enantioselectivities (up to 99% ee).
摘要
以Pd(CF3CO2) 2/(S,S)-联萘酚为催化剂，通过在室温下于2,2,2-三氟乙醇中对相应的环状亚胺进行不对称氢化反应，开发了一种高效的对映选择性合成环状氨基磺酸酯的方法，对映选择性高达99% ee。
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