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A new horizon in primary prevention of cardiovascular disease, can we prevent heart attack by "heart polypill"?

作者信息

Rastegarpanah Mansoor, Malekzadeh Fatemeh, Thomas G Neil, Mohagheghi Abbas, Cheng K K, Marshall Tom

机构信息

Digestive Disease Research Center, Medical Science/University of Tehran, Shariati Hospital, Kargar Shomali Ave, Tehran, Iran.

出版信息

Arch Iran Med. 2008 May;11(3):306-13.

PMID:18426322
Abstract
摘要

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A new horizon in primary prevention of cardiovascular disease, can we prevent heart attack by "heart polypill"?心血管疾病一级预防的新视野，我们能否通过“心脏复方制剂”预防心脏病发作？
Arch Iran Med. 2008 May;11(3):306-13.
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Ask the doctor. I had a heart attack three years ago at age 78. My doctor started me on lisinopril, carvedilol, and aspirin. My total cholesterol is 190, and my LDL is 128. Should I be taking a statin?咨询医生。我78岁，三年前心脏病发作。我的医生让我服用赖诺普利、卡维地洛和阿司匹林。我的总胆固醇是190，低密度脂蛋白是128。我应该服用他汀类药物吗？
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Polypill in cardiovascular disease: has it's time come?心血管疾病中的复方制剂：它的时代来临了吗？
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Primary prevention of myocardial infarction: putting the evidence to use.心肌梗死的一级预防：应用证据
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The Polypill in the prevention of cardiovascular disease.用于预防心血管疾病的复方制剂
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Adding ACE inhibitors or ARBs to standard therapy for stable ischemic heart disease.在稳定型缺血性心脏病的标准治疗方案中添加血管紧张素转换酶抑制剂或血管紧张素Ⅱ受体阻滞剂。
Am Fam Physician. 2012 Jul 1;86(1):21-3.
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Re: Secondary medical prevention in patients with peripheral arterial disease.关于：外周动脉疾病患者的二级医学预防
Eur J Vasc Endovasc Surg. 2008 Jan;35(1):59-60. doi: 10.1016/j.ejvs.2007.07.006. Epub 2007 Aug 27.
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[The polypill: optimal strategy for reduction of cardiovascular disease].[复方制剂：降低心血管疾病的最佳策略]
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Drug secondary prevention in postmenopausal women with ischemic heart disease.绝经后缺血性心脏病女性的药物二级预防
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The clinical performance of an office-based risk scoring system for fatal cardiovascular diseases in North-East of Iran.伊朗东北部基于办公室的致命性心血管疾病风险评分系统的临床性能。
PLoS One. 2015 May 26;10(5):e0126779. doi: 10.1371/journal.pone.0126779. eCollection 2015.
2
Cardiovascular disease mortality and years of life lost attributable to non-optimal systolic blood pressure and hypertension in northeastern Iran.伊朗东北部归因于非最佳收缩压和高血压的心血管疾病死亡率和寿命损失年数。
Arch Iran Med. 2015 Mar;18(3):144-52.
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Polypill for the prevention of cardiovascular disease (PolyIran): study design and rationale for a pragmatic cluster randomized controlled trial.
用于预防心血管疾病的复方制剂（PolyIran）：一项实用整群随机对照试验的研究设计与原理
Eur J Prev Cardiol. 2015 Dec;22(12):1609-17. doi: 10.1177/2047487314550803. Epub 2014 Sep 17.
4
Polypill therapy, subclinical atherosclerosis, and cardiovascular events-implications for the use of preventive pharmacotherapy: MESA (Multi-Ethnic Study of Atherosclerosis).复方药治疗、亚临床动脉粥样硬化和心血管事件——预防性药物治疗的应用意义：MESA（动脉粥样硬化多民族研究）。
J Am Coll Cardiol. 2014 Feb 11;63(5):434-43. doi: 10.1016/j.jacc.2013.08.1640. Epub 2013 Oct 23.
5
The gastro-esophageal malignancies in Northern Iran research project: impact on the health research and health care systems in Iran.伊朗北部胃食管恶性肿瘤研究项目：对伊朗卫生研究和卫生保健系统的影响。
Arch Iran Med. 2013 Jan;16(1):46-53.