Hasani-Ranjbar Shirin, Mohajeri-Tehrani Mohammad-Reza
Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Arch Iran Med. 2008 May;11(3):326-9.
Infiltrative dermopathy is an uncommon manifestation of Graves' disease. The most frequent location of infiltration is the lower extremities, especially the pretibial areas and on the dorsum of the foot. Rarely the hand, elbow, arm, and forearm are affected. We report a 66-year-old man with Graves' disease of nine years duration who presented with dermopathy and nonpitting edema of the toe with no involvement of the pretibial portion since four years ago. Radiologic studies of the foot were normal, without subperiosteal bone formation or reaction. Skin biopsy was consistent with pretibial myxedema. This presentation of myxedema and limitation to a localized area for several years is very unusual.
浸润性皮肤病是格雷夫斯病的一种罕见表现。浸润最常见的部位是下肢，尤其是胫前区和足背。手部、肘部、手臂和前臂很少受累。我们报告一名66岁男性，患格雷夫斯病9年，自4年前以来出现皮肤病和脚趾非凹陷性水肿，胫前部分未受累。足部的放射学检查正常，无骨膜下骨形成或反应。皮肤活检符合胫前黏液性水肿。这种黏液性水肿的表现以及局限于局部区域数年的情况非常罕见。
