大肠杆菌乳糖操纵子双稳性研究的定量方法。
Quantitative approaches to the study of bistability in the lac operon of Escherichia coli.
作者信息
Santillán Moisés, Mackey Michael C
机构信息
Centro de Investigación y Estudios Avanzados del IPN, Unidad Monterrey, Parque de Investigación e Innovación Tecnológica, Apodaca, NL, Mexico.
出版信息
J R Soc Interface. 2008 Aug 6;5 Suppl 1(Suppl 1):S29-39. doi: 10.1098/rsif.2008.0086.focus.
Abstract
In this paper, the history and importance of the lac operon in the development of molecular and systems biology are briefly reviewed. We start by presenting a description of the regulatory mechanisms in this operon, taking into account the most recent discoveries. Then we offer a survey of the history of the lac operon, including the discovery of its main elements and the subsequent influence on the development of molecular and systems biology. Next the bistable behaviour of the operon is discussed, both with respect to its discovery and its molecular origin. A review of the literature in which this bistable phenomenon has been studied from a mathematical modelling viewpoint is then given. We conclude with some brief remarks.
摘要
本文简要回顾了乳糖操纵子在分子生物学和系统生物学发展历程中的历史及重要性。我们首先描述该操纵子的调控机制，并考虑到最新的发现。接着，我们概述乳糖操纵子的历史，包括其主要元件的发现以及对分子生物学和系统生物学发展的后续影响。接下来讨论操纵子的双稳态行为，包括其发现过程及其分子起源。然后给出从数学建模角度研究这一双稳态现象的文献综述。最后给出一些简要评论。
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