霉酚酸在与烟曲霉相互作用期间对人多形核中性粒细胞和树突状细胞功能的影响。
Impact of mycophenolic acid on the functionality of human polymorphonuclear neutrophils and dendritic cells during interaction with Aspergillus fumigatus.
作者信息
Mezger Markus, Wozniok Iwona, Blockhaus Christian, Kurzai Oliver, Hebart Holger, Einsele Hermann, Loeffler Juergen
机构信息
Medizinische Klinik II, Universität Würzburg, 97070 Würzburg, Germany.
出版信息
Antimicrob Agents Chemother. 2008 Jul;52(7):2644-6. doi: 10.1128/AAC.01618-07. Epub 2008 Apr 21.
Abstract
Mycophenolic acid (MPA) is used clinically to prevent graft rejection but may increase the risk of fungal infection. We observed that MPA enhanced the Aspergillus fumigatus-induced oxidative burst of polymorphonuclear neutrophils, but without a corresponding increase in fungal killing. Furthermore, MPA inhibited the proinflammatory cytokine response and maturation of dendritic cells.
摘要
霉酚酸（MPA）在临床上用于预防移植排斥反应，但可能会增加真菌感染的风险。我们观察到，MPA增强了烟曲霉诱导的多形核中性粒细胞的氧化爆发，但真菌杀伤能力并未相应增加。此外，MPA抑制了树突状细胞的促炎细胞因子反应和成熟。
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