Pierce R Christopher, Kalivas Peter W
Boston University School of Medicine, Boston, Massachusetts, USA.
Curr Protoc Neurosci. 2007 Jul;Chapter 8:Unit 8.1. doi: 10.1002/0471142301.ns0801s40.
The study of locomotor activation in rodents does not involve extensive learning or conditioning, and so this dependent measure is often used as the initial screen for pharmacological effects predictive of therapeutic efficacy of a drug class in humans. Methods for evaluating locomotor behavior in rodents fall into two general categories: automated monitoring of behavior and direct observational techniques. This unit presents protocols for measurement of locomotor activity using photocell-based automated monitoring systems, and direct observation using interval and ordinal scales. Other methods used to quantify locomotor activity include video-based systems, rotometers, and running wheels; these are discussed in the commentary. The protocols provided are designed for rats, although they can easily be adapted for use with mice and other rodents.
对啮齿动物运动激活的研究不涉及广泛的学习或条件作用，因此这种相关测量方法常被用作初步筛选，以评估药物类别对人类治疗效果的预测药理作用。评估啮齿动物运动行为的方法大致分为两类：行为的自动监测和直接观察技术。本单元介绍了使用基于光电管的自动监测系统测量运动活动的方案，以及使用间隔量表和顺序量表进行直接观察的方法。用于量化运动活动的其他方法包括基于视频的系统、旋转计和跑步轮；这些将在评论中进行讨论。所提供的方案是为大鼠设计的，不过它们可以很容易地适用于小鼠和其他啮齿动物。
