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基因识别概述:方法、策略及注意事项

An overview of gene identification: approaches, strategies, and considerations.

作者信息

Baxevanis Andreas D

机构信息

National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.

出版信息

Curr Protoc Bioinformatics. 2004 Sep;Chapter 4:Unit4.1. doi: 10.1002/0471250953.bi0401s6.

Abstract

Modern biology is on the verge of officially ushering in a new era in science with the completion of the sequencing of the human genome in April 2003. While often erroneously called the "post-genome era", this will actually truly mark the beginning of the "genome era," a time in which the availability of sequence data for many genomes will have a significant effect on how science is performed in the 21st century. This unit offers an overview of many of the gene prediction methods that are currently available and offers a general assessment of how well the methods work for various problems.

摘要

随着2003年4月人类基因组测序工作的完成,现代生物学即将正式开启科学的新纪元。尽管人们常常错误地称之为“后基因组时代”,但这实际上将真正标志着“基因组时代”的开端。在这个时代,许多基因组序列数据的可得性将对21世纪科学研究的开展方式产生重大影响。本单元概述了目前可用的多种基因预测方法,并对这些方法在解决各种问题时的效果进行了总体评估。

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