Using CorePromoter to find human core promoters.

The CorePromoter program is very useful for identification of transcriptional start sites (TSS) and core promoter regions when 5'-upstream genomic DNA sequences of human genes are available. It is very simple to use and can be accessed either through the Web or after downloading to a local computer. The protocols in this unit introduce its basic methodology and discuss how to apply it to a sample problem in conjunction with other gene-finding programs.