Bellora Nicolás, Farré Domènec, Mar Albà M
Research Unit on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona 08003, Spain.
Bioinformatics. 2007 Jan 15;23(2):243-4. doi: 10.1093/bioinformatics/btl568. Epub 2006 Nov 10.
Many DNA functional motifs tend to accumulate or cluster at specific gene locations. These locations can be detected, in a group of gene sequences, as high frequency 'peaks' with respect to a reference position, such as the transcription start site (TSS). We have developed a web tool for the identification of regions containing significant motif peaks. We show, by using different yeast gene datasets, that peak regions are strongly enriched in experimentally-validated motifs and contain potentially important novel motifs.
许多DNA功能基序倾向于在特定基因位置积累或聚集。在一组基因序列中，相对于参考位置（如转录起始位点（TSS）），这些位置可被检测为高频“峰”。我们开发了一种网络工具来识别包含显著基序峰的区域。通过使用不同的酵母基因数据集，我们表明峰区域在经过实验验证的基序中高度富集，并且包含潜在重要的新基序。
