Washietl Stefan, Hofacker Ivo L
University of Vienna, Vienna, Austria.
Curr Protoc Bioinformatics. 2007 Sep;Chapter 12:Unit 12.7. doi: 10.1002/0471250953.bi1207s19.
The functions of many noncoding RNAs and cis-acting regulatory elements of mRNAs depend on a defined RNA secondary structure. RNAz predicts such functional RNA structures on the basis of thermodynamic stability and evolutionary conservation of homologous sequences. It can be used to efficiently filter multiple alignments for noncoding RNA candidates in genomic screens.
许多非编码RNA的功能以及mRNA的顺式作用调控元件都依赖于特定的RNA二级结构。RNAz基于同源序列的热力学稳定性和进化保守性来预测此类功能性RNA结构。它可用于在基因组筛选中有效地筛选出非编码RNA候选序列的多重比对。
