Cheung Jerry S, Guo Hong, Leung Joseph C K, Man Kwan, Lai Kar N, Wu Ed X
Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong.
Magn Reson Med. 2008 May;59(5):1170-4. doi: 10.1002/mrm.21506.
This study investigated the use of peritoneal dialysis fluid (dialyzate) as a MR contrast agent to visualize the liver structure and peritoneal adhesion in rats at 7 T. Intraperitoneal injection of dialyzate (approximately 0.1 ml/g) yielded excellent and consistent intraperitoneal enhancement that delineated the liver lobular structure in all rats studied (N = 8). It also allowed the MR detection of peritoneal adhesions that were surgically induced. MR measurements of adhesion surface areas correlated well with the postmortem estimations (R = 0.99; N = 6). Dialyzate persisted in the intraperitoneal cavity for up to 2 days. T(1) and T(2) values of undiluted dialyzate were found to be 3017.5 +/- 35.3 ms and 108.4 +/- 2.0 ms, respectively. These findings demonstrated dialyzate-enhanced MRI as a potentially valuable technique to localize certain activities within liver (such as local tumor metastasis), and to monitor therapeutic interventions (e.g., against peritoneal adhesion) in preclinical research using small animal models.
本研究探讨了使用腹膜透析液（透析液）作为磁共振成像（MR）造影剂，在7T磁场下观察大鼠肝脏结构和腹膜粘连情况。腹腔注射透析液（约0.1ml/g）可产生良好且一致的腹腔内强化，清晰显示了所有研究大鼠（N = 8）的肝小叶结构。它还能通过MR检测出手术诱导的腹膜粘连。粘连表面积的MR测量值与尸检估计值相关性良好（R = 0.99；N = 6）。透析液在腹腔内可留存长达2天。未稀释透析液的T(1)和T(2)值分别为3017.5 +/- 35.3毫秒和108.4 +/- 2.0毫秒。这些研究结果表明，在使用小动物模型的临床前研究中，透析液增强MRI是一种潜在的有价值技术，可用于定位肝脏内的某些活动（如局部肿瘤转移），并监测治疗干预措施（如针对腹膜粘连的治疗）。
