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Hydrophobicity profiles for protein sequence analysis.

作者信息

Krystek S R, Metzler W J, Novotny J

机构信息

Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey, USA.

出版信息

Curr Protoc Protein Sci. 2001 May;Chapter 2:Unit2.2. doi: 10.1002/0471140864.ps0202s00.

DOI:10.1002/0471140864.ps0202s00
PMID:18429150
Abstract

Hydrophobic interactions are a major force in protein folding and numerous hydropathy scales have been developed to quantify the relative hydrophobicity of the amino acids. Hydropathy profiles can be used to examine the surface features of proteins in order to generate hypotheses that can be confirmed experimentally. This unit describes the application of hydrophobicity plots to typical problems and provides suggested uses for a few selected scales.

摘要

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