Parente Daniella B, Gasparetto Emerson L, da Cruz Luiz Celso Hygino, Domingues Roberto Cortes, Baptista Ana Célia, Carvalho Antônio Carlos Pires, Domingues Romeu Cortes
Clinica de Diagnóstico Por Imagem, Ave. das Américas 4666, sala 32522649-900, Rio de Janeiro, Brazil.
AJR Am J Roentgenol. 2008 May;190(5):1369-74. doi: 10.2214/AJR.07.2617.
The purpose of this study was to evaluate the fractional anisotropy values of several white matter tracts with the aim of differentiating a healthy population from persons with mild cognitive impairment or Alzheimer's disease.
Seventy-nine patients with memory impairment and 16 volunteer controls participated in the study. MRI was performed with a 1.5-T system. Conventional MR images and diffusion tensor images were obtained for all participants. The diffusion tensor imaging data were postprocessed, and low b-value, fractional anisotropy, and fractional anisotropy color-coded maps were calculated. With the three maps as an anatomic reference, fractional anisotropy was measured for hippocampal formations, superior longitudinal fascicles, posterior cingulate gyri, and the splenium of the corpus callosum. Kruskal-Wallis and Steel-type multiple-comparison nonparametric tests were performed for the statistical analysis.
The fractional anisotropy values for the splenium of the corpus callosum, bilateral posterior cingulate gyri, and bilateral superior longitudinal fascicles of patients with mild cognitive impairment and those with probable Alzheimer's disease were significantly lower than the values of controls. No differences were found in hippocampal formations in any group. No significant difference was found in fractional anisotropy values in comparisons of mild cognitive impairment versus possible Alzheimer's disease and probable Alzheimer's disease or comparisons of probable Alzheimer's disease and possible Alzheimer's disease.
Diffusion tensor imaging is a promising technique for the evaluation of patients with probable mild cognitive impairment. Early detection of the disease expands the treatment options, increasing the likelihood of a good clinical response and enhancing the quality of life of patients and their relatives. Further studies with larger populations are needed to confirm the role of diffusion tensor imaging in the evaluation of memory impairment.
本研究旨在评估几条白质束的各向异性分数值，以区分健康人群与轻度认知障碍或阿尔茨海默病患者。
79名记忆障碍患者和16名志愿者对照参与了本研究。使用1.5-T系统进行磁共振成像（MRI）。为所有参与者获取了常规MR图像和扩散张量图像。对扩散张量成像数据进行后处理，并计算低b值、各向异性分数和各向异性分数彩色编码图。以这三张图作为解剖学参考，测量海马结构、上纵束、后扣带回和胼胝体压部的各向异性分数。进行Kruskal-Wallis和Steel型多重比较非参数检验以进行统计分析。
轻度认知障碍患者和可能患有阿尔茨海默病的患者的胼胝体压部、双侧后扣带回和双侧上纵束的各向异性分数值显著低于对照组。任何组的海马结构均未发现差异。在轻度认知障碍与可能的阿尔茨海默病和可能患有阿尔茨海默病的比较中，或者在可能患有阿尔茨海默病和可能的阿尔茨海默病的比较中，各向异性分数值均未发现显著差异。
扩散张量成像对于评估可能患有轻度认知障碍的患者是一种有前景的技术。疾病的早期检测扩大了治疗选择，增加了良好临床反应的可能性，并提高了患者及其亲属的生活质量。需要进行更大规模人群的进一步研究来证实扩散张量成像在评估记忆障碍中的作用。
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