Assoumou A, Adoubryn K D, Aboum K S, Kouadio-Yapo C G, Ouhon J
Laboratoire de parasitologie-mycologie, UFR des Sciences médicales, BP V 166 Abidjan, Côte d'Ivoire.
Bull Soc Pathol Exot. 2008 Feb;101(1):50-3.
It is commonly admitted that people living in malarial zone are carrying asymptomatic Plasmodium. Côte d'Ivoire is one of these zones. The studies carried out on malaria in these areas have focused mainly on the clinical forms of the disease and effectiveness of the antimalarial drugs. The purpose of this study was to determine the prevalence of the symptomatic and asymptomatic carriage of Plasmodium falciparum in children of 6 months to 180 months old in the Abidjan area. Over a period of twelve months, 902 feverish subjects and 681 non-feverish subjects were selected among the 7,017 people admitted in the paediatrics service of the Abobo general hospital for detection of malaria parasite. Among 1,583 selected subjects, 358 were carrying Plasmodium falciparum implying a total prevalence rate of 22.6%. The prevalence rate was 13.5% and 29.5% respectively in the asymptomatic subjects and symptomatic subjects. The highest proportions of positive thick smears were observed during the long rainy and dry seasons but, parasitaemia was the highest during the short dry season. In 31.5% of the cases, the asymptomatic carriers had a parasitic density higher or equal to 10,000 trophozoites/microl of blood and fever was not related to parasitic load. The prevalence rates of Plasmodium carriage and malaria were higher during the long rainy season. This study highlighted a considerable proportion of asymptomatic Plasmodium falciparum carriers. Improving environmental conditions should help to reduce this rate of carriage.
人们普遍认为,生活在疟疾流行区的人携带无症状疟原虫。科特迪瓦是这些地区之一。在这些地区开展的疟疾研究主要集中在该疾病的临床症状以及抗疟药物的疗效上。本研究的目的是确定阿比让地区6个月至180个月大儿童中恶性疟原虫有症状和无症状携带的患病率。在12个月的时间里,从阿博博综合医院儿科收治的7017名检测疟原虫的患者中,选取了902名发热患者和681名不发热患者。在1583名被选患者中,358人携带恶性疟原虫,总患病率为22.6%。无症状患者和有症状患者的患病率分别为13.5%和29.5%。在漫长的雨季和旱季,厚涂片阳性比例最高,但在短暂的旱季,疟原虫血症最高。在31.5%的病例中,无症状携带者的寄生虫密度高于或等于每微升血液10000个滋养体,且发热与寄生虫载量无关。在漫长的雨季,疟原虫携带率和疟疾患病率更高。本研究突出了相当比例的无症状恶性疟原虫携带者。改善环境条件应有助于降低这种携带率。