甲萘醌环氧化物对兔实验性免疫性关节炎的影响。
The effect of menadione epoxide on the experimental immune arthritis in the rabbit.
作者信息
Pitsillides A A, Blake S M, Glynn L E, Frost G T, Bitensky L, Chayen J
机构信息
Unit of Cellular Pharmacology and Toxicology, Robens Institute of Industrial and Environmental Health and Safety, University of Surrey, Guildford, UK.
出版信息
Int J Exp Pathol. 1991 Jun;72(3):301-9.
It was shown previously that the experimentally induced arthritis in the rabbit can be largely nullified by subsequent treatment with menadione (by gavage). It is now shown that menadione epoxide, as is produced in the vitamin K cycle, also exerts a beneficial effect histologically and biochemically. Such treatment decreased both the glucose 6-phosphate dehydrogenase and the 6-phosphogluconolactonase activities in the synovial lining cells of the challenged joints towards values found in the unchallenged joints; it had only equivocal effects on the 6-phosphogluconate dehydrogenase activity. The results indicated that the epoxide might be interfering primarily with the lactonase activity.
先前的研究表明，通过随后用甲萘醌（经口灌胃）治疗，可在很大程度上消除实验诱导的兔关节炎。现在研究表明，维生素K循环中产生的环氧甲萘醌在组织学和生物化学方面也发挥有益作用。这种治疗使受攻击关节滑膜衬里细胞中的6-磷酸葡萄糖脱氢酶和6-磷酸葡糖酸内酯酶活性均降低至未受攻击关节中的水平；它对6-磷酸葡糖酸脱氢酶活性仅有不明确的影响。结果表明，该环氧化物可能主要干扰内酯酶活性。
Zotero 插件