Fukuta Hidekatsu, Little William C
Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Heart Fail Clin. 2008 Apr;4(2):209-16. doi: 10.1016/j.hfc.2008.01.005.
This article reviews the available evidence from observational studies concerning the effect of statin therapy in patients who have heart failure and a preserved ejection fraction (diastolic heart failure). Observational studies suggest that statin therapy is associated with lower mortality in patients who have diastolic heart failure. These results emphasize the need for a randomized study of the effect of statins in diastolic heart failure. Until the results of such studies are available, it is recommended to use statins in patients with diastolic heart failure who otherwise have an indication for statin therapy.
本文综述了观察性研究中有关他汀类药物治疗对射血分数保留的心力衰竭（舒张性心力衰竭）患者疗效的现有证据。观察性研究表明，他汀类药物治疗与舒张性心力衰竭患者较低的死亡率相关。这些结果强调了对他汀类药物在舒张性心力衰竭中疗效进行随机研究的必要性。在获得此类研究结果之前，建议对有他汀类药物治疗指征的舒张性心力衰竭患者使用他汀类药物。
