Bellinger D C, Trachtenberg F, Zhang A, Tavares M, Daniel D, McKinlay S
Harvard Medical School, Harvard School of Public Health, Children's Hospital, Boston, MA, USA.
J Dent Res. 2008 May;87(5):470-4. doi: 10.1177/154405910808700504.
High-dose exposures to elemental mercury vapor cause emotional dysfunction, but it is uncertain whether the levels of exposure that result from having dental amalgam restorations do so. As part of the New England Children's Amalgam Trial, a randomized trial involving 6- to 10-year-old children, we evaluated the hypothesis that restoration of caries using dental amalgam resulted in worse psychosocial outcomes than restoration using mercury-free composite resin. The primary outcome was the parent-completed Child Behavior Checklist. The secondary outcome was children's self-reports using the Behavior Assessment System for Children. Children's psychosocial status was evaluated in relation to three indices of mercury exposure: treatment assignment, surface-years of amalgam, and urinary mercury excretion. All significant associations favored the amalgam group. No evidence was found that exposure to mercury from dental amalgams was associated with adverse psychosocial outcomes over the five-year period following initial placement of amalgams.
高剂量接触元素汞蒸气会导致情绪功能障碍，但因使用牙科汞合金修复体而产生的接触水平是否会导致这种情况尚不确定。作为新英格兰儿童汞合金试验的一部分，一项涉及6至10岁儿童的随机试验，我们评估了这样一种假设：使用牙科汞合金修复龋齿比使用无汞复合树脂修复产生更差的心理社会结果。主要结局是家长填写的儿童行为检查表。次要结局是儿童使用儿童行为评估系统的自我报告。根据汞接触的三个指标评估儿童的心理社会状况：治疗分配、汞合金表面使用年限和尿汞排泄量。所有显著关联均有利于汞合金组。在首次放置汞合金后的五年期间，未发现有证据表明牙科汞合金中的汞接触与不良心理社会结果相关。
