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麻疹性角膜炎:角膜病变的摄影研究

Rubeola keratitis: a photographic study of corneal lesions.

作者信息

Pavlopoulos Georgios P, Giannakos Georgios I, Theodosiadis Panagiotis G, Moschos Marilita M, Iliakis Evangelos K, Theodosiadis Georgios P

机构信息

Department of Ophthalmology, 401 General Army Hospital of Athens, Athens, Greece.

出版信息

Cornea. 2008 May;27(4):411-6. doi: 10.1097/ICO.0b013e31816313a2.

Abstract

PURPOSE

Detailed description of the morphology of rubeola keratitis lesions is missing from textbooks and published reports. We performed a detailed analysis of rubeola keratitis lesions by using a photographic slit lamp and ophthalmic dyes.

METHODS

Thirty-four eyes of 17 male young adult patients with rubeola keratitis were examined. Patients were examined at 3.6 days after the development of rash. Ocular symptoms were recorded, and patients underwent complete ocular examination including photography of corneal lesions, with and without instillation of ophthalmic dyes (rose Bengal and fluorescein).

RESULTS

Patients complained of foreign-body sensation (88%), photophobia (65%), tearing (65%), and burning sensation (47%). Visual acuity was unaffected (26%) or mildly affected (71%). Conjunctivitis was observed in 74% and keratitis in 100% of eyes. Corneal photographs were studied, and 4 types of corneal lesions were identified: small, punctate epithelial lesions staining only with rose Bengal (100%); small, round, or larger and irregular when they coalesced epithelial defects (100%); large or tiny filaments (39%); and target lesions (100%). Target lesions appeared when both dyes were instilled. The outline of target lesions stained with rose Bengal, and they consisted of a pattern of alternating concentric zones of staining with rose Bengal and fluorescein. Keratitis was strictly confined to the epithelium and resolved gradually in all patients without the appearance of complications.

CONCLUSIONS

Rubeola keratitis in healthy young adults runs a benign course. Recognition of the specific to rubeola keratitis corneal target lesions could aid in the differential diagnosis and prevent the transmission of the disease.

摘要

目的

教科书和已发表的报告中缺少对麻疹角膜炎病变形态的详细描述。我们使用照相裂隙灯和眼科染料对麻疹角膜炎病变进行了详细分析。

方法

对17例患麻疹角膜炎的男性青年成年患者的34只眼进行了检查。在出疹后3.6天对患者进行检查。记录眼部症状,患者接受包括角膜病变照相在内的全面眼部检查,检查时滴入和不滴入眼科染料(孟加拉玫瑰红和荧光素)。

结果

患者主诉有异物感(88%)、畏光(65%)、流泪(65%)和烧灼感(47%)。视力未受影响(26%)或轻度受影响(71%)。74%的眼睛观察到结膜炎,100%的眼睛观察到角膜炎。对角膜照片进行研究,确定了4种角膜病变类型:仅用孟加拉玫瑰红染色的小的点状上皮病变(100%);小的圆形或融合时较大且不规则的上皮缺损(100%);大的或微小的丝状物(39%);以及靶形病变(100%)。滴入两种染料时出现靶形病变。靶形病变用孟加拉玫瑰红染色的轮廓,由孟加拉玫瑰红和荧光素交替染色的同心区域组成。角膜炎严格局限于上皮层,所有患者的角膜炎均逐渐消退,未出现并发症。

结论

健康青年成年人的麻疹角膜炎病程呈良性。认识麻疹角膜炎特有的角膜靶形病变有助于鉴别诊断并预防疾病传播。

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