Jacobi Susan, Dubielzig Richard R
Department of Small Animal Clinical Sciences, Veterinary Teaching Hospital, Michigan State University, East Lansing, MI, USA.
Vet Ophthalmol. 2008 May-Jun;11(3):162-5. doi: 10.1111/j.1463-5224.2008.00614.x.
We have documented the histomorphological features of feline primary open angle glaucoma.
A retrospective morphologic study of eight affected eyes from eight cats, from 1992 to 2006 extracted from a pathology collection, which includes 4000 feline submissions and 1100 cases of feline glaucoma.
Sections of affected globes, stained with H&E or with alcian blue were examined with a light microscope. Eyes that did not fulfill the criteria for primary open angle glaucoma were excluded from the study.
The mean age was 9.1 years. Five cats were female and three cats were male. The breeds included five DSH, two Burmese, and one DLH cat. Significant histomorphological findings included an open irido-corneal angle with an open ciliary cleft in all cases, loss of ganglion cells in eight of eight cases, cupping and gliosis of the optic nerve head in four of four cases in which the optic nerve was adequately sampled, and myxomatous changes of the stroma surrounding the vortex veins in seven of eight cases.
Primary open angle glaucoma in cats is a rare disease that should be taken into consideration when investigating cases of feline glaucoma. The pathogenesis of aqueous outflow obstruction in these cases is not known. This study describes eight additional cases of feline primary open angle glaucoma in cats without an identified cause.
我们已记录了猫原发性开角型青光眼的组织形态学特征。
一项回顾性形态学研究，从1992年至2006年的病理学馆藏中提取了来自8只猫的8只患眼，该馆藏包括4000份猫的送检样本和1100例猫青光眼病例。
用苏木精-伊红（H&E）或阿尔辛蓝染色的患眼球切片，在光学显微镜下进行检查。不符合原发性开角型青光眼标准的眼睛被排除在研究之外。
平均年龄为9.1岁。5只为雌性猫，3只为雄性猫。品种包括5只 Domestic Shorthair（DSH）、2只缅甸猫和1只长毛家猫（DLH）。显著的组织形态学发现包括：所有病例中虹膜角膜角开放且睫状裂开放；8例中有8例神经节细胞缺失；在4例视神经取样充分的病例中，4例均出现视神经乳头杯状凹陷和胶质增生；8例中有7例涡静脉周围基质出现黏液瘤样改变。
猫原发性开角型青光眼是一种罕见疾病，在调查猫青光眼病例时应予以考虑。这些病例中房水流出受阻的发病机制尚不清楚。本研究描述了另外8例未查明病因的猫原发性开角型青光眼病例。
