Kanzaki J, Ogawa K, Ikeda S
Department of Otolaryngology, School of Medicine, Keio University, Tokyo, Japan.
Acta Otolaryngol Suppl. 1991;487:120-4. doi: 10.3109/00016489109130456.
During a 14-year period from 1976 to 1989, the authors experienced 160 cases of acoustic neuroma (AN). The clinical features were investigated in 132 of these cases (excluding those cases of recurrence and neurofibromatosis 2). The cases were divided into three periods for study. There were no significant differences in the patients' age, sex, or affected side among the three periods. The number of intracanalicular tumors have increased in recent years. The proportion of medium-sized and large tumors, however, has not changed, comprising about 70% of the total number of cases. Tumors of 20 mm or smaller in diameter were found in 24% of the cases in the early period, but increased to 58% in the most recent period. There was no difference among the periods in the length of time elapsed from the onset of symptoms to the first examination. A higher proportion of cases were diagnosed in otolaryngology departments in the middle and most recent periods than in the early period. Fewer cases in the most recent period presented initially with disequilibrium or trigeminal nerve symptoms. This was believed to be due to the increase in early stage cases. Patients are increasingly presenting with early stage AN. We feel that in order to support this favorable tendency, more emphasis needs to be placed on early diagnosis.
在1976年至1989年的14年期间，作者共收治160例听神经瘤（AN）患者。对其中132例患者（不包括复发和神经纤维瘤病2型患者）的临床特征进行了调查。将这些病例分为三个时期进行研究。三个时期患者的年龄、性别或患侧无显著差异。近年来，管内型肿瘤的数量有所增加。然而，中大型肿瘤的比例没有变化，约占病例总数的70%。直径20mm及以下的肿瘤在早期病例中占24%，但在最近时期增至58%。从症状出现到首次检查的时间间隔在各时期之间没有差异。与早期相比，中近期在耳鼻喉科确诊的病例比例更高。最近时期最初表现为平衡失调或三叉神经症状的病例较少。这被认为是由于早期病例增加所致。越来越多的患者表现为早期听神经瘤。我们认为，为了支持这种良好趋势，需要更加重视早期诊断。
