代谢综合征中C反应蛋白、白细胞介素-1受体拮抗剂和脂联素水平的性别差异：一项基于人群的研究

Gender differences in C-reactive protein, interleukin-1 receptor antagonist and adiponectin levels in the metabolic syndrome: a population-based study.

作者信息

Saltevo J, Vanhala M, Kautiainen H, Kumpusalo E, Laakso M

机构信息

Department of Internal Medicine, Central Hospital of Middle Finland, Jyväskylä, Finland.

出版信息

Diabet Med. 2008 Jun;25(6):747-50. doi: 10.1111/j.1464-5491.2008.02440.x. Epub 2008 Apr 23.

DOI:10.1111/j.1464-5491.2008.02440.x

PMID:18435780

Abstract

AIMS

We explored gender differences in the association of high-sensitivity C-reactive protein (hs-CRP), interleukin-1 receptor antagonist (IL-1Ra) and adiponectin with the metabolic syndrome (MetS) defined by the National Cholesterol Education Program (NCEP) and the International Diabetes Federation (IDF) criteria.

METHODS

A population-based study of 923 middle-aged subjects in Pieksämäki, East Finland.

RESULTS

The prevalence of the MetS according to the IDF and NCEP definitions was 38% and 34% in men (N = 405) and 34% and 27% in women (N = 497), respectively. hs-CRP and IL-1Ra levels were higher in subjects with the MetS compared with those without the MetS in both sexes (P < 0.001). The levels of hs-CRP (P < 0.001) and IL-1Ra (P = 0.0016 for NCEP criteria, P = 0.0028 for IDF criteria) were significantly higher in women with MetS than in men with MetS. In contrast, in subjects without MetS, no gender differences in the levels of hs-CRP or IL-1Ra were found.

CONCLUSION

Women with MetS, defined by the IDF or NCEP criteria, had higher levels of hs-CRP and IL-1Ra than did men with MetS. Thus, low-grade inflammation may contribute to the high risk of cardiovascular disease in women with MetS.

摘要

目的

我们探讨了高敏C反应蛋白（hs-CRP）、白细胞介素-1受体拮抗剂（IL-1Ra）和脂联素与根据美国国家胆固醇教育计划（NCEP）和国际糖尿病联盟（IDF）标准定义的代谢综合征（MetS）之间关联的性别差异。

方法

对芬兰东部派克斯马基的923名中年受试者进行了一项基于人群的研究。

结果

根据IDF和NCEP定义，男性（N = 405）的MetS患病率分别为38%和34%，女性（N = 497）分别为34%和27%。在患有MetS的受试者中，hs-CRP和IL-1Ra水平在两性中均高于未患MetS的受试者（P < 0.001）。患有MetS的女性的hs-CRP水平（P < 0.001）和IL-1Ra水平（NCEP标准下P = 0.0016，IDF标准下P = 0.0028）显著高于患有MetS的男性。相比之下，在未患MetS的受试者中，未发现hs-CRP或IL-1Ra水平存在性别差异。