Gharipour Mojgan, Ramezani Mohammad Arash, Sadeghi Masuomeh, Khosravi Alireza, Masjedi Mohsen, Khosravi-Boroujeni Hossein, Rafieian-Kopaei Mahmoud, Sarrafzadegan Nizal
Isfahan Cardiovascular Research center, Isfahan, Iran.
J Res Med Sci. 2013 Jun;18(6):467-72.
C-reactive protein (CRP) and white blood cell (WBC) are proinflammatory markers. They are major pathophysiological for the development of metabolic syndrome (MetS). This study aimed to address the independent associations between MetS and WBC counts and serum CRP levels and evaluation of their magnitude in relation to the MetS, based on the sex in the Iranian adults.
In this cross-sectional study, subjects who met the MetS criteria, based on the Adult Treatment Panel III were selected from the Isfahan Healthy Heart Program database. A questionnaire containing the demographic data, weight, height, waist, and hip circumference of the respondents was completed for each person. Blood pressure was measured and the anthropometric measurements were done, and fasting blood samples were taken for 2 h postload plasma glucose (2 hpp). Serum [total, high-density lipoprotein (HDL), and low-density lipoprotein] levels of cholesterol, triglyceride, and CRP as well as WBC counts were determined. The univariate analyses were carried out to assess the relation between the CRP levels, WBC counts with the MetS in both sexes the.
In men with the abdominal obesity, the higher levels of WBC count, high serum triglyceride and blood glucose levels, a low serum HDL level, and raised systolic and diastolic blood pressure were observed. However, the higher serum CRP levels were only observed in those with the low serum HDL-cholesterol levels. The mean values of the WBC counts were statistically different between the men with and without MetS, but the mean values of the CRP levels were similar between the two groups. In women, the mean values of WBC count and CRP levels were statistically different in the subjects with and without a MetS components (except for the low serum HDL levels and high diastolic blood pressure for the WBC measures and abdominal obesity for the CRP measures) and for those with and without MetS. The age and smoking adjusted changes in the CRP levels and WBC counts correlated with the number of Mets components in the women.
The findings of this study suggest substantial implications for the prevention and management of the MetS and atherosclerotic diseases, as these involve the suppression of inflammatory conditions rather than the incitement of anti-inflammatory conditions.
C反应蛋白（CRP）和白细胞（WBC）是促炎标志物。它们是代谢综合征（MetS）发生发展的主要病理生理因素。本研究旨在探讨伊朗成年人中MetS与白细胞计数及血清CRP水平之间的独立关联，并根据性别评估它们与MetS的关联程度。
在这项横断面研究中，从伊斯法罕健康心脏项目数据库中选取符合基于成人治疗小组第三次报告（Adult Treatment Panel III）标准的MetS受试者。为每个人填写一份包含受访者人口统计学数据、体重、身高、腰围和臀围的问卷。测量血压并进行人体测量，采集空腹血样以测定餐后2小时血浆葡萄糖（2 hpp）。测定血清总胆固醇、高密度脂蛋白（HDL）、低密度脂蛋白胆固醇、甘油三酯、CRP水平以及白细胞计数。进行单因素分析以评估男女CRP水平、白细胞计数与MetS之间的关系。
在腹型肥胖男性中，观察到白细胞计数、血清甘油三酯和血糖水平较高，血清HDL水平较低，收缩压和舒张压升高。然而，仅在血清HDL胆固醇水平较低的男性中观察到较高的血清CRP水平。有MetS和无MetS的男性白细胞计数平均值在统计学上有差异，但两组CRP水平平均值相似。在女性中，有和无MetS组分的受试者以及有和无MetS的受试者中，白细胞计数和CRP水平平均值在统计学上有差异（白细胞测量中血清HDL水平低和舒张压高以及CRP测量中腹型肥胖除外）。年龄和吸烟调整后的CRP水平和白细胞计数变化与女性MetS组分数量相关。
本研究结果表明，对于MetS和动脉粥样硬化疾病的预防和管理具有重要意义，因为这些疾病涉及抑制炎症状态而非激发抗炎状态。
