Young Jane M, Solomon Michael J, Harrison James D, Salkeld Glenn, Butow Phyllis
Surgical Outcomes Research Centre, University of Sydney and Royal Prince Albert Hospital, Sydney, Australia.
Surgery. 2008 May;143(5):582-8. doi: 10.1016/j.surg.2008.01.009.
One of the major barriers to randomized trials in the field of surgery is the presence of strong preferences for one of the treatment options. Patients and surgeons who favor strongly a particular treatment approach are usually reluctant to participate in trials where operative intervention is determined on the basis of randomization. This then affects both the feasibility of the trial in terms of achieving the required sample size as well as the generalizability of the study's findings. Therefore, measurement of patient and surgeon preference is a crucial component of the feasibility assessment for surgery trials. In this article, we introduce the Prospective Measure of Preference, which is a novel method to measure preferences that has been designed to accommodate the complexity of surgical decision-making. We also present a simple method to measure individual and community equipoise among expert clinicians to assess the feasibility of future randomized trials in surgery.
外科领域随机试验的主要障碍之一是对其中一种治疗方案存在强烈偏好。强烈倾向于某种特定治疗方法的患者和外科医生通常不愿参与基于随机化确定手术干预的试验。这进而影响到试验在达到所需样本量方面的可行性以及研究结果的可推广性。因此，测量患者和外科医生的偏好是外科试验可行性评估的关键组成部分。在本文中，我们介绍了偏好的前瞻性测量方法，这是一种旨在适应外科决策复杂性而设计的测量偏好的新方法。我们还提出了一种简单的方法来测量专家临床医生之间的个体和群体平衡，以评估未来外科随机试验的可行性。
