Black Donald W, Shaw Martha C, Allen Jeff
University of Iowa Roy J. and Lucille A. Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1191-4. doi: 10.1016/j.pnpbp.2008.02.013. Epub 2008 Mar 7.
The efficacy and tolerability of extended release carbamazepine was tested in the treatment of pathological gambling (PG).
Non-depressed outpatients with DSM-IV PG received flexibly dosed extended release carbamazepine in a prospective 10-week open-label trial following a two-week observation period. Subjects were evaluated at baseline and at one week intervals during a four week titration period, and every two weeks thereafter for assessment of gambling behavior, mood, and adverse experiences. The primary efficacy measure was the Yale-Brown Obsessive-Compulsive Scale modified for PG (YBOCS-PG).
Eight subjects (6 men, 2 women) had at least one post-baseline visit, and five subjects (63%) completed the protocol. Significant improvement was found on the YBOCS-PG (P< .001). Seven of the eight subjects with post-baseline assessment (88%) were considered responders (i.e., achieved "much" or "very much" improvement on the CGI). Four subjects (50%) abstained from gambling during their final month of study participation. Several patients were dropped because of adverse experiences.
The results suggest that extended release carbamazepine may be effective in the treatment of PG.
对缓释卡马西平治疗病理性赌博（PG）的疗效和耐受性进行了测试。
患有DSM-IV病理性赌博的非抑郁门诊患者在为期两周的观察期后，参加了一项为期10周的前瞻性开放标签试验，接受灵活剂量的缓释卡马西平治疗。在为期四周的滴定期内，于基线和每隔一周对受试者进行评估，此后每两周评估一次赌博行为、情绪和不良经历。主要疗效指标是针对病理性赌博修改后的耶鲁-布朗强迫量表（YBOCS-PG）。
八名受试者（6名男性，2名女性）至少进行了一次基线后访视，五名受试者（63%）完成了试验方案。在YBOCS-PG上发现有显著改善（P<0.001）。在进行了基线后评估的八名受试者中，有七名（88%）被视为有反应者（即在临床总体印象量表上取得了“很多”或“非常多”的改善）。四名受试者（50%）在参与研究的最后一个月内停止了赌博。有几名患者因不良经历而退出。
结果表明，缓释卡马西平可能对治疗病理性赌博有效。
