小儿高血压:近期趋势与成就、未来挑战

Pediatric hypertension: recent trends and accomplishments, future challenges.

作者信息

Flynn Joseph T

机构信息

Division of Nephrology, Children's Hospital and Regional Medical Center, Seattle, Washington, USA.

出版信息

Am J Hypertens. 2008 Jun;21(6):605-12. doi: 10.1038/ajh.2008.159. Epub 2008 Apr 17.

Abstract

Publication of the Fourth Report on high blood pressure (BP) in children and adolescents by the National High BP Education Program (NHBPEP) in 2004 has been followed by a remarkable increase in interest in pediatric hypertension. New data have emerged on the epidemiology of hypertension in the young, the influence of the childhood obesity epidemic on BP, how ambulatory BP monitoring (ABPM) can be used in evaluating elevated BP and the extent of hypertensive target-organ damage in the pediatric age group. Exciting new information on drug treatment of pediatric hypertension has been produced by industry-sponsored clinical trials of antihypertensive medications spurred by the FDA Modernization Act (FDAMA) and successor legislation. Despite these trends, recognition of elevated BP in children and adolescents by primary care providers remains problematic. This article will highlight these and other aspects of pediatric hypertension, hopefully providing a snapshot of where we are in early 2008, and pointing out areas where further work is needed in order to reduce the future burden of adult cardiovascular disease.

摘要

2004年,国家高血压教育计划(NHBPEP)发布了关于儿童和青少年高血压的第四次报告,此后人们对儿童高血压的兴趣显著增加。关于青少年高血压流行病学、儿童肥胖流行对血压的影响、动态血压监测(ABPM)如何用于评估血压升高以及儿科年龄组高血压靶器官损害程度的新数据不断涌现。由美国食品药品监督管理局现代化法案(FDAMA)及其后续立法推动的行业赞助的抗高血压药物临床试验产生了关于儿童高血压药物治疗的令人兴奋的新信息。尽管有这些趋势,但初级保健提供者对儿童和青少年血压升高的认识仍然存在问题。本文将重点介绍儿童高血压的这些及其他方面,希望能呈现出我们在2008年初的情况,并指出为减轻未来成人心血管疾病负担还需要进一步开展工作的领域。

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