Goodwin Pamela J, Ennis Marguerite, Bahl Mala, Fantus I George, Pritchard Kathleen I, Trudeau Maureen E, Koo Jarley, Hood Nicky
Department of Medicine, Division of Clinical Epidemiology at the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 1284-600 University Avenue, Toronto, ON, Canada M5G 1X5.
Breast Cancer Res Treat. 2009 Apr;114(3):517-25. doi: 10.1007/s10549-008-0019-0. Epub 2008 Apr 25.
High insulin levels have been associated with poor outcomes in breast cancer. Our goal was to investigate whether hyperinsulinemia was associated with insulin resistance in a cohort of newly diagnosed locoregional breast cancer patients and to examine associations of hyperinsulinemia with the broader insulin resistance syndrome (IRS).
Five hundred and four women with T1-3, N0-1, M0 breast cancer provided fasting blood that was analyzed for glucose, insulin and lipids. They underwent anthropomorphic measurements and provided information on diet, exercise and sleep. Relationships of insulin with three validated indices of insulin resistance and with attributes of the IRS were examined.
High insulin levels were strongly correlated with insulin resistance calculated using the three indices of insulin resistance/sensitivity (Spearman r=0.83-0.98). Hyperinsulinemia was also associated with other components of the IRS (obesity, high waist-hip ratio, lipid profile).
High insulin levels in women with locoregional breast cancer reflect the presence of insulin resistance and are associated with other components of the IRS. These observations have implications for the development of therapies that target hyperinsulinemia in early stage breast cancer and for the long-term management of breast cancer survivors.
高胰岛素水平与乳腺癌预后不良相关。我们的目标是在一组新诊断的局部区域乳腺癌患者中研究高胰岛素血症是否与胰岛素抵抗相关，并探讨高胰岛素血症与更广泛的胰岛素抵抗综合征（IRS）之间的关联。
504名患有T1 - 3、N0 - 1、M0期乳腺癌的女性提供了空腹血液，用于分析血糖、胰岛素和血脂。她们接受了人体测量，并提供了有关饮食、运动和睡眠的信息。研究了胰岛素与三种经过验证的胰岛素抵抗指标以及与IRS特征之间的关系。
高胰岛素水平与使用三种胰岛素抵抗/敏感性指标计算出的胰岛素抵抗密切相关（斯皮尔曼r = 0.83 - 0.98）。高胰岛素血症还与IRS的其他组成部分（肥胖、高腰臀比、血脂谱）相关。
局部区域乳腺癌女性的高胰岛素水平反映了胰岛素抵抗的存在，并与IRS的其他组成部分相关。这些观察结果对针对早期乳腺癌高胰岛素血症的治疗方法的开发以及乳腺癌幸存者的长期管理具有重要意义。
