DL-α-二氟甲基鸟氨酸（DFMO）-贝尼尔组合：对小鼠布氏布氏锥虫感染的治疗和预防活性。
DL-alpha-difluoromethylornithine (DFMO)-Berenil combination: therapeutic and prophylactic activity against Trypanosoma brucei brucei infection in mice.
作者信息
Onyeyili P A, Egwu G O, Zaria L T, Orjiude B A
机构信息
Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Maiduguri, Nigeria.
出版信息
Rev Elev Med Vet Pays Trop. 1991;44(4):443-5.
The therapeutic and prophylactic activity of difluoromethylornithine (DFMO) (2% in drinking water for 4 days) and Berenil (7 mg/kg live weight intraperitoneally) combination was investigated in mice infected with Trypanosoma brucei brucei. Using a previously described mouse model of the African trypanosomosis of the central nervous system, it was demonstrated that the combination was curative and acted synergistically. However, if used prophylactically it had no advantage over Berenil alone.
研究了二氟甲基鸟氨酸（DFMO）（饮用水中含2%，持续4天）与贝尼尔（7毫克/千克体重，腹腔注射）联合用药对感染布氏布氏锥虫小鼠的治疗和预防活性。使用先前描述的中枢神经系统非洲锥虫病小鼠模型，结果表明该联合用药具有治愈作用且表现出协同作用。然而，若用于预防，它并不比单独使用贝尼尔更具优势。
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