二氟甲基鸟氨酸（DFMO）与乙酰氨基阿苯达唑联合治疗大鼠晚期布氏布氏锥虫感染的疗效。
Efficacy of combination of DFMO and diminazene aceturate in the treatment of late stage Trypanosoma brucei brucei infection in rats.
作者信息
Onyeyili P A, Onwualu J E
机构信息
Department of Veterinary Physiology and Pharmacology, University of Maiduguri, Nigeria.
出版信息
Trop Med Parasitol. 1991 Jun;42(2):143-5.
The therapeutic activity of difluoromethylornithine and diminazene aceturate alone and in combination was investigated in albino rats with late stage Trypanosoma brucei brucei infection. The criteria used in the assessment of the trypanocidal effect of the compounds include the degree of parasitaemia, and frequency of relapse and death. DFMO (4 percent administered in drinking water for 6 days) and diminazene aceturate (10 mg per kg intraperitoneal) produced an intermittent aparasitaemia with relapse occurring in the two groups. A combination of the two agents produced a permanent cure. The combination of the two agents appear to act synergistically in the treatment of T.b. brucei C.N.S. infection in rats.
在患有晚期布氏布氏锥虫感染的白化大鼠中，研究了二氟甲基鸟氨酸和乙酰氨基阿维菌素单独及联合使用的治疗活性。评估这些化合物杀锥虫效果的标准包括寄生虫血症程度、复发频率和死亡频率。二氟甲基鸟氨酸（在饮用水中给予4%，持续6天）和乙酰氨基阿维菌素（每公斤腹腔注射10毫克）产生了间歇性无寄生虫血症，两组均出现复发。两种药物联合使用产生了永久性治愈。这两种药物联合使用似乎在治疗大鼠布氏布氏锥虫中枢神经系统感染中具有协同作用。
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