Schleicher Michael, Jockusch Brigitte M
Adolf-Butenandt-Institute, Cell Biology and Center for Integrated Protein Science (CIPSM), Ludwig-Maximilians-University, 80336, Munich, Germany.
Histochem Cell Biol. 2008 Jun;129(6):695-704. doi: 10.1007/s00418-008-0430-y. Epub 2008 Apr 26.
In this article, we follow the history of one of the most abundant, most intensely studied proteins of the eukaryotic cells: actin. We report on hallmarks of its discovery, its structural and functional characterization and localization over time, and point to present days' knowledge on its position as a member of a large family. We focus on the rather puzzling number of diverse functions as proposed for actin as a dual compartment protein. Finally, we venture on some speculations as to its origin.
在本文中，我们追溯了真核细胞中最丰富、研究最深入的蛋白质之一——肌动蛋白的历史。我们报告了其发现的标志、随时间推移的结构和功能特征及定位，并指出了目前关于其作为一个大家族成员地位的认识。我们聚焦于肌动蛋白作为一种双区室蛋白所具有的相当令人费解的多种功能。最后，我们对其起源进行了一些推测。
