Ximenes-da-Silva A, Guedes R C
Departamento de Nutrição, Universidade Federal de Pernambuco, Recife, PE, Brasil.
Braz J Med Biol Res. 1991;24(12):1277-81.
The effects of intravenous glucose (1 ml, 40% solution) and insulin (1.5-3.0 U/kg in 0.2-0.4 ml Ringer solution) on the velocity of propagation (VP) of cortical spreading depression (SD) were studied in 36 well-nourished (W) and 25 malnourished (M) adult (90 days old) Wistar rats of both sexes. Blood glucose levels, measured 40-70 min after glucose, were increased by 330% in the W group (N = 18) and by 202.9% in the M rats (N = 12), when compared to the pre-injection levels. Insulin decreased it by 43.5% and 61.2% in W and M rats, respectively (N = 13). In the W rats, SD VP decreased after glucose and increased after insulin. The effect of glucose could not be attributed to increases in blood osmolarity, since iv mannitol (1 ml, 20% solution, N = 5) failed to decrease SD VP. The mean +/- SEM VP before and after the treatments were as follows (in mm/min): W rats, glucose 3.31 +/- 0.16 and 3.11 +/- 0.13; insulin 3.50 +/- 0.12 and 3.81 +/- 0.11; mannitol 3.53 +/- 0.46 and 3.92 +/- 0.48. In the M rats, the above effects on SD were not seen (SD VP: glucose 3.89 +/- 0.20 and 4.13 +/- 0.24; insulin 3.51 +/- 0.19 and 3.63 +/- 0.17). The results suggest that changes in the production of brain energy influence SD propagation.
在36只营养良好（W）和25只营养不良（M）的成年（90日龄）雌雄Wistar大鼠中，研究了静脉注射葡萄糖（1毫升，40%溶液）和胰岛素（1.5 - 3.0单位/千克，溶于0.2 - 0.4毫升林格溶液）对皮质扩散性抑制（SD）传播速度（VP）的影响。与注射前水平相比，在葡萄糖注射后40 - 70分钟测量的血糖水平，W组（N = 18）升高了330%，M组大鼠（N = 12）升高了202.9%。胰岛素分别使W组和M组大鼠的血糖水平降低了43.5%和61.2%（N = 13）。在W组大鼠中，葡萄糖注射后SD的VP降低，胰岛素注射后升高。葡萄糖的这种作用不能归因于血液渗透压的升高，因为静脉注射甘露醇（1毫升，20%溶液，N = 5）未能降低SD的VP。治疗前后的平均±SEM VP如下（单位：毫米/分钟）：W组大鼠，葡萄糖分别为3.31±0.16和3.11±0.13；胰岛素分别为3.50±0.12和3.81±0.11；甘露醇分别为3.53±0.46和3.92±0.48。在M组大鼠中，未观察到上述对SD的影响（SD的VP：葡萄糖分别为3.89±0.20和4.13±0.24；胰岛素分别为3.51±0.19和3.63±0.17）。结果表明，脑能量产生的变化会影响SD的传播。
